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Research Article

Identification of Hammerhead Ribozymes in All Domains of Life Reveals Novel Structural Variations

  • Jonathan Perreault,

    Affiliation: Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut, United States of America

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  • Zasha Weinberg,

    Affiliations: Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut, United States of America, Howard Hughes Medical Institute, Yale University, New Haven, Connecticut, United States of America

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  • Adam Roth,

    Affiliations: Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut, United States of America, Howard Hughes Medical Institute, Yale University, New Haven, Connecticut, United States of America

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  • Olivia Popescu,

    Affiliation: Department of Biochemistry, Université de Montréal, Montréal, Québec, Canada

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  • Pascal Chartrand,

    Affiliation: Department of Biochemistry, Université de Montréal, Montréal, Québec, Canada

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  • Gerardo Ferbeyre,

    Affiliation: Department of Biochemistry, Université de Montréal, Montréal, Québec, Canada

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  • Ronald R. Breaker mail

    ronald.breaker@yale.edu

    Affiliations: Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut, United States of America, Howard Hughes Medical Institute, Yale University, New Haven, Connecticut, United States of America, Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America

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  • Published: May 05, 2011
  • DOI: 10.1371/journal.pcbi.1002031

About the Authors

Jonathan Perreault, Zasha Weinberg, Adam Roth, Ronald R. Breaker
Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut, United States of America
Zasha Weinberg, Adam Roth, Ronald R. Breaker
Howard Hughes Medical Institute, Yale University, New Haven, Connecticut, United States of America
Ronald R. Breaker
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America
Olivia Popescu, Pascal Chartrand, Gerardo Ferbeyre
Department of Biochemistry, Université de Montréal, Montréal, Québec, Canada

Corresponding Author

Email: ronald.breaker@yale.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JP ZW AR PC GF RRB. Performed the experiments: JP ZW AR OP. Analyzed the data: JP ZW AR PC GF RRB. Contributed reagents/materials/analysis tools: PC GF RRB. Wrote the paper: JP AR RRB.