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Research Article

Quantitative Epistasis Analysis and Pathway Inference from Genetic Interaction Data

  • Hilary Phenix,

    Affiliations: Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada

    X
  • Katy Morin,

    Affiliations: Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada, Department of Biochemistry, Immunology and Microbiology, University of Ottawa, Ottawa, Ontario, Canada

    X
  • Cory Batenchuk,

    Affiliations: Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada

    X
  • Jacob Parker,

    Affiliations: Ottawa Hospital Research Institute, Ottawa, Ontario, Canada, Department of Applied Mathematics, University of Waterloo, Waterloo, Ontario, Canada

    X
  • Vida Abedi,

    Affiliations: Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada

    X
  • Liu Yang,

    Affiliations: Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada, Department of Applied Mathematics, University of Waterloo, Waterloo, Ontario, Canada

    X
  • Lioudmila Tepliakova,

    Affiliations: Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada

    X
  • Theodore J. Perkins,

    Affiliations: Department of Biochemistry, Immunology and Microbiology, University of Ottawa, Ottawa, Ontario, Canada, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

    X
  • Mads Kærn mail

    mkaern@uottawa.ca

    Affiliations: Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada, Department of Physics, University of Ottawa, Ottawa, Ontario, Canada

    X
  • Published: May 12, 2011
  • DOI: 10.1371/journal.pcbi.1002048

About the Authors

Hilary Phenix, Katy Morin, Cory Batenchuk, Vida Abedi, Liu Yang, Lioudmila Tepliakova, Mads Kærn
Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada
Hilary Phenix, Cory Batenchuk, Vida Abedi, Liu Yang, Lioudmila Tepliakova, Mads Kærn
Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada
Katy Morin, Theodore J. Perkins
Department of Biochemistry, Immunology and Microbiology, University of Ottawa, Ottawa, Ontario, Canada
Jacob Parker, Theodore J. Perkins
Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
Jacob Parker, Liu Yang
Department of Applied Mathematics, University of Waterloo, Waterloo, Ontario, Canada
Mads Kærn
Department of Physics, University of Ottawa, Ottawa, Ontario, Canada

Corresponding Author

Email: mkaern@uottawa.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HP TJP MK. Performed the experiments: HP KM LT. Analyzed the data: HP KM CB MK. Contributed reagents/materials/analysis tools: HP KM CB JP LT TJP MK. Wrote the paper: HP TJP MK. Conducted preliminary analyses of alternative inference methods: VA LY.