About the Authors

Hilary Phenix

Affiliations Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada

Katy Morin

Affiliations Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada, Department of Biochemistry, Immunology and Microbiology, University of Ottawa, Ottawa, Ontario, Canada

Cory Batenchuk

Affiliations Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada

Jacob Parker

Affiliations Ottawa Hospital Research Institute, Ottawa, Ontario, Canada, Department of Applied Mathematics, University of Waterloo, Waterloo, Ontario, Canada

Vida Abedi

Affiliations Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada

Liu Yang

Affiliations Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada, Department of Applied Mathematics, University of Waterloo, Waterloo, Ontario, Canada

Lioudmila Tepliakova

Affiliations Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada

Theodore J. Perkins

Affiliations Department of Biochemistry, Immunology and Microbiology, University of Ottawa, Ottawa, Ontario, Canada, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

Mads Kærn

mkaern@uottawa.ca

Affiliations Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada, Department of Physics, University of Ottawa, Ottawa, Ontario, Canada

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HP TJP MK. Performed the experiments: HP KM LT. Analyzed the data: HP KM CB MK. Contributed reagents/materials/analysis tools: HP KM CB JP LT TJP MK. Wrote the paper: HP TJP MK. Conducted preliminary analyses of alternative inference methods: VA LY.