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Research Article

An Acidic Loop and Cognate Phosphorylation Sites Define a Molecular Switch That Modulates Ubiquitin Charging Activity in Cdc34-Like Enzymes

  • Elena Papaleo mail,

    elena.papaleo@unimib.it (EP); paola.coccetti@unimib.it (PC)

    Affiliation: Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy

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  • Valeria Ranzani,

    Affiliation: Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy

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  • Farida Tripodi,

    Affiliation: Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy

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  • Alessandro Vitriolo,

    Affiliation: Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy

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  • Claudia Cirulli,

    Affiliation: Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy

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  • Piercarlo Fantucci,

    Affiliation: Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy

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  • Lilia Alberghina,

    Affiliation: Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy

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  • Marco Vanoni,

    Affiliation: Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy

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  • Luca De Gioia,

    Affiliation: Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy

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  • Paola Coccetti mail

    elena.papaleo@unimib.it (EP); paola.coccetti@unimib.it (PC)

    Affiliation: Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy

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  • Published: May 26, 2011
  • DOI: 10.1371/journal.pcbi.1002056

About the Authors

Elena Papaleo, Valeria Ranzani, Farida Tripodi, Alessandro Vitriolo, Claudia Cirulli, Piercarlo Fantucci, Lilia Alberghina, Marco Vanoni, Luca De Gioia, Paola Coccetti
Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EP FT PC. Performed the experiments: EP VR FT AV CC. Analyzed the data: EP VR FT CC MV PC. Wrote the paper: EP FT PF LA MV LDG PC.