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Research Article

Differential Producibility Analysis (DPA) of Transcriptomic Data with Metabolic Networks: Deconstructing the Metabolic Response of M. tuberculosis

  • Bhushan K. Bonde,

    Affiliation: Microbial Sciences Division, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom

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  • Dany J. V. Beste,

    Affiliation: Microbial Sciences Division, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom

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  • Emma Laing,

    Affiliation: Microbial Sciences Division, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom

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  • Andrzej M. Kierzek,

    Affiliation: Microbial Sciences Division, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom

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  • Johnjoe McFadden mail

    j.mcfadden@surrey.ac.uk

    Affiliation: Microbial Sciences Division, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom

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  • Published: June 30, 2011
  • DOI: 10.1371/journal.pcbi.1002060

About the Authors

Bhushan K. Bonde, Dany J. V. Beste, Emma Laing, Andrzej M. Kierzek, Johnjoe McFadden
Microbial Sciences Division, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom

Corresponding Author

Email: j.mcfadden@surrey.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BKB AMK JM . Performed the experiments: BKB DJVB. Analyzed the data: BKB EL AMK. Contributed reagents/materials/analysis tools: BKB. Wrote the paper: BKB JM.