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Research Article

Construction and Modelling of an Inducible Positive Feedback Loop Stably Integrated in a Mammalian Cell-Line

  • Velia Siciliano,

    Affiliation: Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy

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  • Filippo Menolascina equal contributor,

    equal contributor Contributed equally to this work with: Filippo Menolascina, Lucia Marucci

    Affiliations: Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy, Department of Computer and Systems Engineering, Federico II University, Naples, Italy

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  • Lucia Marucci equal contributor,

    equal contributor Contributed equally to this work with: Filippo Menolascina, Lucia Marucci

    Affiliations: Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy, Department of Computer and Systems Engineering, Federico II University, Naples, Italy

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  • Chiara Fracassi,

    Affiliation: Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy

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  • Immacolata Garzilli,

    Affiliation: Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy

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  • Maria Nicoletta Moretti,

    Affiliation: Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy

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  • Diego di Bernardo mail

    dibernardo@tigem.it

    Affiliations: Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy, Department of Computer and Systems Engineering, Federico II University, Naples, Italy

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  • Published: June 30, 2011
  • DOI: 10.1371/journal.pcbi.1002074
  • Featured in PLOS Collections

About the Authors

Velia Siciliano, Filippo Menolascina, Lucia Marucci, Chiara Fracassi, Immacolata Garzilli, Maria Nicoletta Moretti, Diego di Bernardo
Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy
Filippo Menolascina, Lucia Marucci, Diego di Bernardo
Department of Computer and Systems Engineering, Federico II University, Naples, Italy

Corresponding Author

Email: dibernardo@tigem.it

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: VS DdB. Performed the experiments: VS FM CF MNM. Analyzed the data: VS FM LM CF IG. Contributed reagents/materials/analysis tools: MNM. Wrote the paper: VS FM LM CF IG DdB.