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Research Article

Boltzmann Energy-based Image Analysis Demonstrates that Extracellular Domain Size Differences Explain Protein Segregation at Immune Synapses

  • Nigel J. Burroughs mail,

    N.J.Burroughs@warwick.ac.uk

    Affiliation: Systems Biology Centre, University of Warwick, Coventry, United Kingdom

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  • Karsten Köhler,

    Affiliation: Cambridge Institute for Medical Research, Addenbrookes Hospital, Cambridge, United Kingdom

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  • Vladimir Miloserdov,

    Affiliation: Systems Biology Centre, University of Warwick, Coventry, United Kingdom

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  • Michael L. Dustin,

    Affiliation: Skirball Institute of Biomolecular Medicine, New York University, New York, New York, United States of America

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  • P. Anton van der Merwe,

    Affiliation: Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom

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  • Daniel M. Davis

    Affiliation: Division of Cell and Molecular Biology, Imperial College London, London, United Kingdom

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  • Published: August 04, 2011
  • DOI: 10.1371/journal.pcbi.1002076

About the Authors

Nigel J. Burroughs, Vladimir Miloserdov
Systems Biology Centre, University of Warwick, Coventry, United Kingdom
Karsten Köhler
Cambridge Institute for Medical Research, Addenbrookes Hospital, Cambridge, United Kingdom
Michael L. Dustin
Skirball Institute of Biomolecular Medicine, New York University, New York, New York, United States of America
P. Anton van der Merwe
Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
Daniel M. Davis
Division of Cell and Molecular Biology, Imperial College London, London, United Kingdom

Corresponding Author

Email: N.J.Burroughs@warwick.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NJB KK PAvdM DMD. Performed the experiments: KK. Analyzed the data: NJB VM. Contributed reagents/materials/analysis tools: NJB MLD PAvdM DMD. Wrote the paper: NJB.