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Research Article

Interrogation of the Protein-Protein Interactions between Human BRCA2 BRC Repeats and RAD51 Reveals Atomistic Determinants of Affinity

  • Daniel J. Cole,

    Affiliation: Theory of Condensed Matter Group, Cavendish Laboratory, University of Cambridge, Cambridge, United Kingdom

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  • Eeson Rajendra,

    Affiliation: MRC Cancer Cell Unit Hutchison/MRC Research Centre, Cambridge, United Kingdom

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  • Meredith Roberts-Thomson,

    Affiliation: Cambridge Molecular Therapeutics Programme, Hutchison/MRC Research Centre, Cambridge, United Kingdom

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  • Bryn Hardwick,

    Affiliations: MRC Cancer Cell Unit Hutchison/MRC Research Centre, Cambridge, United Kingdom, Cambridge Molecular Therapeutics Programme, Hutchison/MRC Research Centre, Cambridge, United Kingdom

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  • Grahame J. McKenzie,

    Affiliations: MRC Cancer Cell Unit Hutchison/MRC Research Centre, Cambridge, United Kingdom, Cambridge Molecular Therapeutics Programme, Hutchison/MRC Research Centre, Cambridge, United Kingdom

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  • Mike C. Payne,

    Affiliation: Theory of Condensed Matter Group, Cavendish Laboratory, University of Cambridge, Cambridge, United Kingdom

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  • Ashok R. Venkitaraman mail,

    arv@hutchison-mrc.cam.ac.uk(ARV); C.Skylaris@soton.ac.uk(CKS)

    Affiliations: MRC Cancer Cell Unit Hutchison/MRC Research Centre, Cambridge, United Kingdom, Cambridge Molecular Therapeutics Programme, Hutchison/MRC Research Centre, Cambridge, United Kingdom

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  • Chris-Kriton Skylaris mail

    arv@hutchison-mrc.cam.ac.uk(ARV); C.Skylaris@soton.ac.uk(CKS)

    Affiliation: School of Chemistry, University of Southampton, Highfield, Southampton, United Kingdom

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  • Published: July 14, 2011
  • DOI: 10.1371/journal.pcbi.1002096

About the Authors

Daniel J. Cole, Mike C. Payne
Theory of Condensed Matter Group, Cavendish Laboratory, University of Cambridge, Cambridge, United Kingdom
Eeson Rajendra, Bryn Hardwick, Grahame J. McKenzie, Ashok R. Venkitaraman
MRC Cancer Cell Unit Hutchison/MRC Research Centre, Cambridge, United Kingdom
Meredith Roberts-Thomson, Bryn Hardwick, Grahame J. McKenzie, Ashok R. Venkitaraman
Cambridge Molecular Therapeutics Programme, Hutchison/MRC Research Centre, Cambridge, United Kingdom
Chris-Kriton Skylaris
School of Chemistry, University of Southampton, Highfield, Southampton, United Kingdom

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DJC ER MRT BH GJM MCP ARV CKS. Performed the experiments: DJC MRT BH. Analyzed the data: DJC ER MRT BH GJM CKS. Wrote the paper: DJC ER CKS. Revised the manuscript: MCP ARV.