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Research Article

Understanding the Origins of Bacterial Resistance to Aminoglycosides through Molecular Dynamics Mutational Study of the Ribosomal A-Site

  • Julia Romanowska mail,

    jrom@icm.edu.pl

    Affiliations: Department of Biophysics, Faculty of Physics, University of Warsaw, Warsaw Poland, Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw, Warsaw, Poland

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  • J. Andrew McCammon,

    Affiliations: Department of Chemistry and Biochemistry, University of California, San Diego, California, United States of America, Center for Theoretical Biological Physics, University of California, San Diego, California, United States of America, Department of Pharmacology, University of California, San Diego, California, United States of America, Howard Hughes Medical Institute, University of California, San Diego, California, United States of America

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  • Joanna Trylska

    Affiliation: Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw, Warsaw, Poland

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  • Published: July 21, 2011
  • DOI: 10.1371/journal.pcbi.1002099

About the Authors

Julia Romanowska
Department of Biophysics, Faculty of Physics, University of Warsaw, Warsaw Poland
Julia Romanowska, Joanna Trylska
Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw, Warsaw, Poland
J. Andrew McCammon
Department of Chemistry and Biochemistry, University of California, San Diego, California, United States of America
J. Andrew McCammon
Center for Theoretical Biological Physics, University of California, San Diego, California, United States of America
J. Andrew McCammon
Department of Pharmacology, University of California, San Diego, California, United States of America
J. Andrew McCammon
Howard Hughes Medical Institute, University of California, San Diego, California, United States of America

Corresponding Author

Email: jrom@icm.edu.pl

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JR JT. Performed the experiments: JR. Analyzed the data: JR JT. Wrote the paper: JR JAM JT.