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Research Article

A Peptide Filtering Relation Quantifies MHC Class I Peptide Optimization

  • Neil Dalchau equal contributor mail,

    equal contributor Contributed equally to this work with: Neil Dalchau, Andrew Phillips

    ndalchau@microsoft.com

    Affiliation: Biological Computation Group, Microsoft Research, Cambridge, United Kingdom

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  • Andrew Phillips equal contributor,

    equal contributor Contributed equally to this work with: Neil Dalchau, Andrew Phillips

    Affiliation: Biological Computation Group, Microsoft Research, Cambridge, United Kingdom

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  • Leonard D. Goldstein,

    Affiliation: Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Centre for Mathematical Sciences, Cambridge, United Kingdom

    Current address: Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, United Kingdom.

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  • Mark Howarth,

    Affiliations: Faculty of Medicine, University of Southampton, Southampton, United Kingdom, Department of Biochemistry, Oxford University, Oxford, United Kingdom

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  • Luca Cardelli,

    Affiliation: Programming Principles and Tools Group, Microsoft Research, Cambridge, United Kingdom

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  • Stephen Emmott,

    Affiliation: Biological Computation Group, Microsoft Research, Cambridge, United Kingdom

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  • Tim Elliott,

    Affiliations: Faculty of Medicine, University of Southampton, Southampton, United Kingdom, Institute for Life Sciences, University of Southampton, Southampton, United Kingdom

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  • Joern M. Werner

    Affiliations: Institute for Life Sciences, University of Southampton, Southampton, United Kingdom, School of Biological Sciences, Faculty of Natural Sciences and the Environment, University of Southampton, Southampton, United Kingdom

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  • Published: October 13, 2011
  • DOI: 10.1371/journal.pcbi.1002144

About the Authors

Neil Dalchau, Andrew Phillips, Stephen Emmott
Biological Computation Group, Microsoft Research, Cambridge, United Kingdom
Leonard D. Goldstein
Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Centre for Mathematical Sciences, Cambridge, United Kingdom
Mark Howarth, Tim Elliott
Faculty of Medicine, University of Southampton, Southampton, United Kingdom
Mark Howarth
Department of Biochemistry, Oxford University, Oxford, United Kingdom
Luca Cardelli
Programming Principles and Tools Group, Microsoft Research, Cambridge, United Kingdom
Tim Elliott, Joern M. Werner
Institute for Life Sciences, University of Southampton, Southampton, United Kingdom
Joern M. Werner
School of Biological Sciences, Faculty of Natural Sciences and the Environment, University of Southampton, Southampton, United Kingdom

Corresponding Author

Email: ndalchau@microsoft.com

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ND AP MH LC TE JMW. Performed the experiments: ND AP LDG MH. Analyzed the data: ND MH. Contributed reagents/materials/analysis tools: AP. Wrote the paper: ND AP LDG MH LC SE TE JMW.