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Research Article

A Switching Mechanism in Doxorubicin Bioactivation Can Be Exploited to Control Doxorubicin Toxicity

  • Nnenna A. Finn,

    Affiliation: Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia

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  • Harry W. Findley,

    Affiliation: The Division of Pediatric Hematology/Oncology, Emory University School of Medicine, Atlanta, Georgia

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  • Melissa L. Kemp mail

    melissa.kemp@bme.gatech.edu

    Affiliation: Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia

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  • Published: September 15, 2011
  • DOI: 10.1371/journal.pcbi.1002151

About the Authors

Nnenna A. Finn, Melissa L. Kemp
Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia
Harry W. Findley
The Division of Pediatric Hematology/Oncology, Emory University School of Medicine, Atlanta, Georgia

Corresponding Author

Email: melissa.kemp@bme.gatech.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NAF MLK. Performed the experiments: NAF. Analyzed the data: NAF MLK. Contributed reagents/materials/analysis tools: HWF MLK. Wrote the paper: NAF MLK.