About the Authors

T. M. Murali

murali@cs.vt.edu (TMM) (TM); honey@u.washington.edu (MGK) (MK)

Affiliation Department of Computer Science, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America

Matthew D. Dyer

Contributed equally to this work with: Matthew D. Dyer, David Badger

Affiliation Applied Biosystems, Foster City, California, United States of America

David Badger

Contributed equally to this work with: Matthew D. Dyer, David Badger

Affiliation Department of Computer Science, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America

Brett M. Tyler

These authors also contributed equally to this work.

Affiliation Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America

Michael G. Katze

murali@cs.vt.edu (TMM) (TM); honey@u.washington.edu (MGK) (MK)

These authors also contributed equally to this work.

Affiliation Department of Microbiology, University of Washington, Seattle, Washington, United States of America

Competing Interests

I have read the journal's policy and have the following conflicts: MDD is employed by and owns stock in Life Technologies.

Author Contributions

Conceived and designed the experiments: TMM MDD. Performed the experiments: TMM. Analyzed the data: TMM MDD BMT MGK. Contributed reagents/materials/analysis tools: TMM MDD DB BMT. Wrote the paper: TMM MDD BMT MGK. Conceived and designed the algorithm used in analysis: TMM BMT. Designed and implemented the software used in analysis: TMM DB.