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Research Article

High-Precision, In Vitro Validation of the Sequestration Mechanism for Generating Ultrasensitive Dose-Response Curves in Regulatory Networks

  • Francesco Ricci equal contributor,

    equal contributor Contributed equally to this work with: Francesco Ricci, Alexis Vallée-Bélisle

    Affiliations: Department of Chemistry and Biochemistry, University of California, Santa Barbara, California, United States of America, Dipartimento di Scienze e Tecnologie Chimiche, University of Rome, Tor Vergata, Rome, Italy, Consorzio Interuniversitario Biostrutture e Biosistemi “INBB”, Rome, Italy

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  • Alexis Vallée-Bélisle equal contributor,

    equal contributor Contributed equally to this work with: Francesco Ricci, Alexis Vallée-Bélisle

    Affiliation: Department of Chemistry and Biochemistry, University of California, Santa Barbara, California, United States of America

    X
  • Kevin W. Plaxco mail

    kwp@chem.ucsb.edu

    Affiliations: Department of Chemistry and Biochemistry, University of California, Santa Barbara, California, United States of America, Interdepartmental Program in Biomolecular Science and Engineering, University of California, Santa Barbara, California, United States of America

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  • Published: October 06, 2011
  • DOI: 10.1371/journal.pcbi.1002171
  • Featured in PLOS Collections

About the Authors

Francesco Ricci, Alexis Vallée-Bélisle, Kevin W. Plaxco
Department of Chemistry and Biochemistry, University of California, Santa Barbara, California, United States of America
Francesco Ricci
Dipartimento di Scienze e Tecnologie Chimiche, University of Rome, Tor Vergata, Rome, Italy
Francesco Ricci
Consorzio Interuniversitario Biostrutture e Biosistemi “INBB”, Rome, Italy
Kevin W. Plaxco
Interdepartmental Program in Biomolecular Science and Engineering, University of California, Santa Barbara, California, United States of America

Corresponding Author

Email: kwp@chem.ucsb.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: FR AVB KWP. Performed the experiments: FR AVB. Analyzed the data: FR AVB KWP. Contributed reagents/materials/analysis tools: FR AVB KWP. Wrote the paper: FR AVB KWP.