Network Models of TEM β-Lactamase Mutations Coevolving under Antibiotic Selection Show Modular Structure and Anticipate Evolutionary Trajectories

Violeta Beleva Guthrie; Jennifer Allen; Manel Camps; Rachel Karchin

doi:10.1371/journal.pcbi.1002184

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Peer-reviewed

Research Article

Network Models of TEM β-Lactamase Mutations Coevolving under Antibiotic Selection Show Modular Structure and Anticipate Evolutionary Trajectories

Violeta Beleva Guthrie,

Affiliation Department of Biomedical Engineering and Institute for Computational Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America
⨯
Jennifer Allen,

Affiliation Department of Environmental Toxicology, University of California Santa Cruz, Santa Cruz, California, United States of America
⨯
Manel Camps ,

¶MC and RC both served as co-mentors for VBG.

Affiliation Department of Environmental Toxicology, University of California Santa Cruz, Santa Cruz, California, United States of America
⨯
Rachel Karchin

* E-mail: karchin@jhu.edu

¶MC and RC both served as co-mentors for VBG.

Affiliation Department of Biomedical Engineering and Institute for Computational Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America
⨯

Network Models of TEM β-Lactamase Mutations Coevolving under Antibiotic Selection Show Modular Structure and Anticipate Evolutionary Trajectories

Violeta Beleva Guthrie,
Jennifer Allen,
Manel Camps,
Rachel Karchin

Published: September 22, 2011
https://doi.org/10.1371/journal.pcbi.1002184

About the Authors

Violeta Beleva Guthrie

Affiliation Department of Biomedical Engineering and Institute for Computational Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America

Jennifer Allen

Affiliation Department of Environmental Toxicology, University of California Santa Cruz, Santa Cruz, California, United States of America

Manel Camps

¶MC and RC both served as co-mentors for VBG.

Affiliation Department of Environmental Toxicology, University of California Santa Cruz, Santa Cruz, California, United States of America

Rachel Karchin

* E-mail: karchin@jhu.edu

¶MC and RC both served as co-mentors for VBG.

Affiliation Department of Biomedical Engineering and Institute for Computational Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: VBG MC RK. Performed the experiments: VBG JA. Analyzed the data: VBG MC RK. Contributed reagents/materials/analysis tools: VBG MC RK. Wrote the paper: VBG MC RK.

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Mutation databases
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Centrality
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Antibiotic resistance
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Evolutionary adaptation
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Coevolution
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Epistasis
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Fitness epistasis
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Antibiotics
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