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Research Article

Transmission Selects for HIV-1 Strains of Intermediate Virulence: A Modelling Approach

  • George Shirreff,

    Affiliation: Medical Research Council Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College, London, United Kingdom

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  • Lorenzo Pellis,

    Affiliation: Medical Research Council Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College, London, United Kingdom

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  • Oliver Laeyendecker,

    Affiliations: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Baltimore, Maryland, United States of America, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Christophe Fraser mail

    c.fraser@imperial.ac.uk

    Affiliation: Medical Research Council Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College, London, United Kingdom

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  • Published: October 13, 2011
  • DOI: 10.1371/journal.pcbi.1002185

About the Authors

George Shirreff, Lorenzo Pellis, Christophe Fraser
Medical Research Council Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College, London, United Kingdom
Oliver Laeyendecker
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Baltimore, Maryland, United States of America
Oliver Laeyendecker
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Corresponding Author

Email: c.fraser@imperial.ac.uk

Competing Interests

The authors declare that they have no financial, personal, or professional interests in conflict with the findings in this paper.

Author Contributions

Conceived and designed the experiments: GS LP CF. Performed the experiments: GS. Analyzed the data: GS CF. Contributed reagents/materials/analysis tools: GS LP CF. Wrote the paper: GS CF. Provided the data to which the model was fit: OL.