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Research Article

Changes in Dynamics upon Oligomerization Regulate Substrate Binding and Allostery in Amino Acid Kinase Family Members

  • Enrique Marcos,

    Affiliation: Department of Biological Chemistry and Molecular Modelling, IQAC-CSIC, Barcelona, Spain

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  • Ramon Crehuet mail,

    rcsqtc@iqac.csic.es (RC) (RC); bahar@ccbb.pitt.edu (IB) (IB)

    Affiliation: Department of Biological Chemistry and Molecular Modelling, IQAC-CSIC, Barcelona, Spain

    X
  • Ivet Bahar mail

    rcsqtc@iqac.csic.es (RC) (RC); bahar@ccbb.pitt.edu (IB) (IB)

    Affiliation: Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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  • Published: September 29, 2011
  • DOI: 10.1371/journal.pcbi.1002201

About the Authors

Enrique Marcos, Ramon Crehuet
Department of Biological Chemistry and Molecular Modelling, IQAC-CSIC, Barcelona, Spain
Ivet Bahar
Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EM RC IB. Performed the experiments: EM. Analyzed the data: EM RC IB. Contributed reagents/materials/analysis tools: EM RC IB. Wrote the paper: EM RC IB.