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Research Article

Automatic Morphological Subtyping Reveals New Roles of Caspases in Mitochondrial Dynamics

  • Jyh-Ying Peng equal contributor mail,

    equal contributor Contributed equally to this work with: Jyh-Ying Peng, Chung-Chih Lin

    jypeng@ym.edu.tw (JYP); chunnan@iis.sinica.edu.tw (CNH)

    Affiliations: Institute of Biomedical Informatics, National Yang-Ming University, Taipei, Taiwan, Taipei City Hospital, Taipei, Taiwan

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  • Chung-Chih Lin equal contributor,

    equal contributor Contributed equally to this work with: Jyh-Ying Peng, Chung-Chih Lin

    Affiliation: Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei, Taiwan

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  • Yen-Jen Chen,

    Affiliation: Institute of Information Science, Academia Sinica, Taipei, Taiwan

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  • Lung-Sen Kao,

    Affiliation: Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei, Taiwan

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  • Young-Chau Liu,

    Affiliation: College of Liberal Education, Shu-Te University, Kaohsiung City, Taiwan

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  • Chung-Chien Chou,

    Affiliation: Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei, Taiwan

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  • Yi-Hung Huang,

    Affiliations: Institute of Information Science, Academia Sinica, Taipei, Taiwan, Department of Computer Science and Information Engineering, National Taiwan University, Taipei, Taiwan

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  • Fang-Rong Chang,

    Affiliation: Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan

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  • Yang-Chang Wu,

    Affiliations: Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan, Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan

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  • Yuh-Show Tsai,

    Affiliation: Graduate Institute of Biomedical Engineering, Chung-Yuan Christian University, Zhongli City, Taiwan

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  • Chun-Nan Hsu mail

    jypeng@ym.edu.tw (JYP); chunnan@iis.sinica.edu.tw (CNH)

    Affiliations: Institute of Information Science, Academia Sinica, Taipei, Taiwan, Information Sciences Institute, University of Southern California, Marina del Rey, California, United States of America

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  • Published: October 06, 2011
  • DOI: 10.1371/journal.pcbi.1002212

About the Authors

Jyh-Ying Peng
Institute of Biomedical Informatics, National Yang-Ming University, Taipei, Taiwan
Jyh-Ying Peng
Taipei City Hospital, Taipei, Taiwan
Chung-Chih Lin, Lung-Sen Kao, Chung-Chien Chou
Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei, Taiwan
Yen-Jen Chen, Yi-Hung Huang, Chun-Nan Hsu
Institute of Information Science, Academia Sinica, Taipei, Taiwan
Young-Chau Liu
College of Liberal Education, Shu-Te University, Kaohsiung City, Taiwan
Yi-Hung Huang
Department of Computer Science and Information Engineering, National Taiwan University, Taipei, Taiwan
Fang-Rong Chang, Yang-Chang Wu
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan
Yang-Chang Wu
Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan
Yuh-Show Tsai
Graduate Institute of Biomedical Engineering, Chung-Yuan Christian University, Zhongli City, Taiwan
Chun-Nan Hsu
Information Sciences Institute, University of Southern California, Marina del Rey, California, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JYP CCL LSK YCL. Performed the experiments: CCL CCC. Analyzed the data: JYP YJC YHH YST CNH. Contributed reagents/materials/analysis tools: FRC YCW. Wrote the paper: JYP CCL CNH.