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Research Article

Near-Native Protein Loop Sampling Using Nonparametric Density Estimation Accommodating Sparcity

  • Hyun Joo equal contributor,

    equal contributor Contributed equally to this work with: Hyun Joo, Archana G. Chavan

    Affiliation: Department of Chemistry, University of the Pacific, Stockton, California, United States of America

    X
  • Archana G. Chavan equal contributor,

    equal contributor Contributed equally to this work with: Hyun Joo, Archana G. Chavan

    Affiliation: Department of Chemistry, University of the Pacific, Stockton, California, United States of America

    X
  • Ryan Day,

    Affiliation: Department of Chemistry, University of the Pacific, Stockton, California, United States of America

    X
  • Kristin P. Lennox,

    Affiliation: Department of Statistics, Texas A&M University, College Station, Texas, United States of America

    X
  • Paul Sukhanov,

    Affiliation: Department of Chemistry, University of the Pacific, Stockton, California, United States of America

    X
  • David B. Dahl,

    Affiliation: Department of Statistics, Texas A&M University, College Station, Texas, United States of America

    X
  • Marina Vannucci,

    Affiliation: Department of Statistics, Rice University, Houston, Texas, United States of America

    X
  • Jerry Tsai mail

    jtsai@pacific.edu

    Affiliation: Department of Chemistry, University of the Pacific, Stockton, California, United States of America

    X
  • Published: October 20, 2011
  • DOI: 10.1371/journal.pcbi.1002234

About the Authors

Hyun Joo, Archana G. Chavan, Ryan Day, Paul Sukhanov, Jerry Tsai
Department of Chemistry, University of the Pacific, Stockton, California, United States of America
Kristin P. Lennox, David B. Dahl
Department of Statistics, Texas A&M University, College Station, Texas, United States of America
Marina Vannucci
Department of Statistics, Rice University, Houston, Texas, United States of America

Corresponding Author

Email: jtsai@pacific.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HJ RD KPL DBD MV JT. Performed the experiments: HJ AGC RD KPL PS. Analyzed the data: HJ AGC RD PS. Contributed reagents/materials/analysis tools: HJ AGC RD KPL DBD MV JT. Wrote the paper: HJ AGC RD PS JT.