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Research Article

NHE Inhibition Does Not Improve Na+ or Ca2+ Overload During Reperfusion: Using Modeling to Illuminate the Mechanisms Underlying a Therapeutic Failure

  • Byron N. Roberts,

    Affiliation: Greenberg Division of Cardiology and Department of Physiology, Biophysics and Systems Biology, Weill Cornell Medical College, New York, New York, United States of America

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  • David J. Christini mail

    dchristi@med.cornell.edu

    Affiliation: Greenberg Division of Cardiology and Department of Physiology, Biophysics and Systems Biology, Weill Cornell Medical College, New York, New York, United States of America

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  • Published: October 20, 2011
  • DOI: 10.1371/journal.pcbi.1002241

About the Authors

Byron N. Roberts, David J. Christini
Greenberg Division of Cardiology and Department of Physiology, Biophysics and Systems Biology, Weill Cornell Medical College, New York, New York, United States of America

Corresponding Author

Email: dchristi@med.cornell.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BNR DJC. Performed the experiments: BNR. Analyzed the data: BNR. Contributed reagents/materials/analysis tools: BNR. Wrote the paper: BNR DJC.