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Research Article

Metabolic Regulation in Progression to Autoimmune Diabetes

  • Marko Sysi-Aho,

    Affiliation: VTT Technical Research Centre of Finland, Espoo, Finland

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  • Andrey Ermolov,

    Affiliation: Aalto University School of Science, Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Espoo, Finland

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  • Peddinti V. Gopalacharyulu,

    Affiliation: VTT Technical Research Centre of Finland, Espoo, Finland

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  • Abhishek Tripathi,

    Affiliation: Helsinki Institute for Information Technology HIIT, Department of Computer Science, University of Helsinki, Finland

    Current address: Xerox Research Centre Europe, Meylan, France

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  • Tuulikki Seppänen-Laakso,

    Affiliation: VTT Technical Research Centre of Finland, Espoo, Finland

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  • Johanna Maukonen,

    Affiliation: VTT Technical Research Centre of Finland, Espoo, Finland

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  • Ismo Mattila,

    Affiliation: VTT Technical Research Centre of Finland, Espoo, Finland

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  • Suvi T. Ruohonen,

    Affiliation: Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, Finland

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  • Laura Vähätalo,

    Affiliation: Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, Finland

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  • Laxman Yetukuri,

    Affiliation: VTT Technical Research Centre of Finland, Espoo, Finland

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  • Taina Härkönen,

    Affiliation: Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland

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  • Erno Lindfors,

    Affiliation: VTT Technical Research Centre of Finland, Espoo, Finland

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  • Janne Nikkilä,

    Affiliation: Finnish Red Cross Blood Service, Helsinki, Finland

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  • Jorma Ilonen,

    Affiliations: Department of Clinical Microbiology, University of Eastern Finland, Kuopio, Finland, Immunogenetics Laboratory, University of Turku, Turku, Finland

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  • Olli Simell,

    Affiliation: Department of Pediatrics, University of Turku, Turku, Finland

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  • Maria Saarela,

    Affiliation: VTT Technical Research Centre of Finland, Espoo, Finland

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  • Mikael Knip,

    Affiliations: Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland, Department of Pediatrics, Tampere University Hospital, Tampere, Finland, Folkhälsan Research Center, Helsinki, Finland

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  • Samuel Kaski,

    Affiliations: Aalto University School of Science, Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Espoo, Finland, Helsinki Institute for Information Technology HIIT, Department of Computer Science, University of Helsinki, Finland

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  • Eriika Savontaus,

    Affiliations: Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, Finland, Unit of Clinical Pharmacology, Turku University Hospital, Turku, Finland

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  • Matej Orešič mail

    matej.oresic@vtt.fi

    Affiliations: VTT Technical Research Centre of Finland, Espoo, Finland, Institute of Molecular Medicine Finland FIMM, Helsinki, Finland

    X
  • Published: October 27, 2011
  • DOI: 10.1371/journal.pcbi.1002257

About the Authors

Marko Sysi-Aho, Peddinti V. Gopalacharyulu, Tuulikki Seppänen-Laakso, Johanna Maukonen, Ismo Mattila, Laxman Yetukuri, Erno Lindfors, Maria Saarela, Matej Orešič
VTT Technical Research Centre of Finland, Espoo, Finland
Andrey Ermolov, Samuel Kaski
Aalto University School of Science, Department of Information and Computer Science, Helsinki Institute for Information Technology HIIT, Espoo, Finland
Abhishek Tripathi, Samuel Kaski
Helsinki Institute for Information Technology HIIT, Department of Computer Science, University of Helsinki, Finland
Suvi T. Ruohonen, Laura Vähätalo, Eriika Savontaus
Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, Finland
Taina Härkönen, Mikael Knip
Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
Janne Nikkilä
Finnish Red Cross Blood Service, Helsinki, Finland
Jorma Ilonen
Department of Clinical Microbiology, University of Eastern Finland, Kuopio, Finland
Jorma Ilonen
Immunogenetics Laboratory, University of Turku, Turku, Finland
Olli Simell
Department of Pediatrics, University of Turku, Turku, Finland
Mikael Knip
Department of Pediatrics, Tampere University Hospital, Tampere, Finland
Mikael Knip
Folkhälsan Research Center, Helsinki, Finland
Eriika Savontaus
Unit of Clinical Pharmacology, Turku University Hospital, Turku, Finland
Matej Orešič
Institute of Molecular Medicine Finland FIMM, Helsinki, Finland

Corresponding Author

Email: matej.oresic@vtt.fi

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SK ES MO. Performed the experiments: TSL JM IM STR LV TH MS. Analyzed the data: MSA AE PVG AT LY EL JN SK MO. Contributed reagents/materials/analysis tools: JI OS MS MK ES MO. Wrote the paper: MO.