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Research Article

Replication Pauses of the Wild-Type and Mutant Mitochondrial DNA Polymerase Gamma: A Simulation Study

  • Zhuo Song,

    Affiliation: Center for Human Genetic Research, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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  • Yang Cao,

    Affiliation: Department of Computer Science, Virginia Tech, Blacksburg, Virginia, United States of America

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  • David C. Samuels mail

    david.samuels@chgr.mc.vanderbilt.edu

    Affiliation: Center for Human Genetic Research, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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  • Published: November 17, 2011
  • DOI: 10.1371/journal.pcbi.1002287

About the Authors

Zhuo Song, David C. Samuels
Center for Human Genetic Research, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
Yang Cao
Department of Computer Science, Virginia Tech, Blacksburg, Virginia, United States of America

Corresponding Author

Email: david.samuels@chgr.mc.vanderbilt.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ZS DCS. Performed the experiments: ZS. Analyzed the data: ZS DCS. Contributed reagents/materials/analysis tools: YC. Wrote the paper: ZS DCS. Algorithm design: YC Software: ZS.