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Research Article

Increased Vulnerability of Human Ventricle to Re-entrant Excitation in hERG-linked Variant 1 Short QT Syndrome

  • Ismail Adeniran,

    Affiliation: Biological Physics Group, School of Physics & Astronomy, The University of Manchester, Manchester, United Kingdom

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  • Mark J. McPate,

    Affiliation: Department of Physiology and Cardiovascular Research Laboratories, School of Medical Sciences, Bristol, United Kingdom

    Current address: Novartis Institutes for Biomedical Research, Horsham, West Sussex, United Kingdom

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  • Harry J. Witchel,

    Affiliation: Department of Physiology and Cardiovascular Research Laboratories, School of Medical Sciences, Bristol, United Kingdom

    Current address: Brighton and Sussex Medical School, Falmer, United Kingdom

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  • Jules C. Hancox mail,

    henggui.zhang@manchester.ac.uk (HZ); jules.hancox@bristol.ac.uk (JCH)

    Affiliation: Department of Physiology and Cardiovascular Research Laboratories, School of Medical Sciences, Bristol, United Kingdom

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  • Henggui Zhang mail

    henggui.zhang@manchester.ac.uk (HZ); jules.hancox@bristol.ac.uk (JCH)

    Affiliation: Biological Physics Group, School of Physics & Astronomy, The University of Manchester, Manchester, United Kingdom

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  • Published: December 15, 2011
  • DOI: 10.1371/journal.pcbi.1002313

About the Authors

Ismail Adeniran, Henggui Zhang
Biological Physics Group, School of Physics & Astronomy, The University of Manchester, Manchester, United Kingdom
Mark J. McPate, Harry J. Witchel, Jules C. Hancox
Department of Physiology and Cardiovascular Research Laboratories, School of Medical Sciences, Bristol, United Kingdom

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HZ JCH. Performed the experiments: IA. Analyzed the data: IA HZ JCH. Wrote the paper: IA HZ JCH. In vitro hERG data used to validate WT and mutant IKr formulations: MJM HJW.