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Research Article

Switches, Excitable Responses and Oscillations in the Ring1B/Bmi1 Ubiquitination System

  • Lan K. Nguyen equal contributor,

    equal contributor Contributed equally to this work with: Lan K. Nguyen, Javier Muñoz-García

    Affiliation: Systems Biology Ireland, University College Dublin, Belfield, Dublin, Ireland

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  • Javier Muñoz-García equal contributor,

    equal contributor Contributed equally to this work with: Lan K. Nguyen, Javier Muñoz-García

    Affiliation: Systems Biology Ireland, University College Dublin, Belfield, Dublin, Ireland

    X
  • Helene Maccario,

    Affiliation: Systems Biology Ireland, University College Dublin, Belfield, Dublin, Ireland

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  • Aaron Ciechanover,

    Affiliation: Cancer and Vascular Biology Research Center, The Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology, Bat Galim, Haifa, Israel

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  • Walter Kolch,

    Affiliation: Systems Biology Ireland, University College Dublin, Belfield, Dublin, Ireland

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  • Boris N. Kholodenko mail

    boris.kholodenko@ucd.ie

    Affiliations: Systems Biology Ireland, University College Dublin, Belfield, Dublin, Ireland, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Published: December 15, 2011
  • DOI: 10.1371/journal.pcbi.1002317

About the Authors

Lan K. Nguyen, Javier Muñoz-García, Helene Maccario, Walter Kolch, Boris N. Kholodenko
Systems Biology Ireland, University College Dublin, Belfield, Dublin, Ireland
Aaron Ciechanover
Cancer and Vascular Biology Research Center, The Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology, Bat Galim, Haifa, Israel
Boris N. Kholodenko
Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

Corresponding Author

Email: boris.kholodenko@ucd.ie

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LKN JMG HM AC WK BNK. Performed the experiments: LKN JMG HM BNK. Analyzed the data: LKN JMG HM BNK. Contributed reagents/materials/analysis tools: LKN JMG HM BNK. Wrote the paper: LKN JMG AC WK BNK.