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Research Article

The Rates of Protein Synthesis and Degradation Account for the Differential Response of Neurons to Spaced and Massed Training Protocols

  • Faisal Naqib,

    Affiliation: Department of Physiology, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada

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  • Carole A. Farah,

    Affiliation: Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada

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  • Christopher C. Pack,

    Affiliations: Department of Physiology, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada

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  • Wayne S. Sossin mail

    wayne.sossin@mcgill.ca

    Affiliation: Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada

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  • Published: December 29, 2011
  • DOI: 10.1371/journal.pcbi.1002324

About the Authors

Faisal Naqib, Christopher C. Pack
Department of Physiology, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
Carole A. Farah, Christopher C. Pack, Wayne S. Sossin
Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada

Corresponding Author

Email: wayne.sossin@mcgill.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: FN WSS. Performed the experiments: FN CAF. Analyzed the data: FN CAF CCP WSS. Contributed reagents/materials/analysis tools: FN CAF WSS. Wrote the paper: FN WSS CAF CCP.