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Research Article

Macro-level Modeling of the Response of C. elegans Reproduction to Chronic Heat Stress

  • Patrick D. McMullen equal contributor,

    equal contributor Contributed equally to this work with: Patrick D. McMullen, Erin Z. Aprison, Peter B. Winter

    Affiliation: Department of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois, United States of America

    X
  • Erin Z. Aprison equal contributor,

    equal contributor Contributed equally to this work with: Patrick D. McMullen, Erin Z. Aprison, Peter B. Winter

    Affiliation: Department of Ecology and Evolution, Institute for Genomics and Systems Biology, The University of Chicago, Chicago, Illinois, United States of America

    X
  • Peter B. Winter equal contributor,

    equal contributor Contributed equally to this work with: Patrick D. McMullen, Erin Z. Aprison, Peter B. Winter

    Affiliation: Department of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois, United States of America

    X
  • Luis A. N. Amaral mail,

    amaral@northwestern.edu (LANA); r-morimoto@northwestern.edu (RIM); ruvinsky@uchicago.edu (IR)

    Affiliation: Department of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois, United States of America

    X
  • Richard I. Morimoto mail,

    amaral@northwestern.edu (LANA); r-morimoto@northwestern.edu (RIM); ruvinsky@uchicago.edu (IR)

    Affiliation: Department of Molecular Biosciences, Rice Institute for Biomedical Sciences, Northwestern University, Evanston, Illinois, United States of America

    X
  • Ilya Ruvinsky mail

    amaral@northwestern.edu (LANA); r-morimoto@northwestern.edu (RIM); ruvinsky@uchicago.edu (IR)

    Affiliation: Department of Ecology and Evolution, Institute for Genomics and Systems Biology, The University of Chicago, Chicago, Illinois, United States of America

    X
  • Published: January 26, 2012
  • DOI: 10.1371/journal.pcbi.1002338

About the Authors

Patrick D. McMullen, Peter B. Winter, Luis A. N. Amaral
Department of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois, United States of America
Erin Z. Aprison, Ilya Ruvinsky
Department of Ecology and Evolution, Institute for Genomics and Systems Biology, The University of Chicago, Chicago, Illinois, United States of America
Richard I. Morimoto
Department of Molecular Biosciences, Rice Institute for Biomedical Sciences, Northwestern University, Evanston, Illinois, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LANA RIM IR. Performed the experiments: PDM EZA PBW. Analyzed the data: PDM EZA PBW LANA RIM IR. Wrote the paper: PDM EZA PBW LANA RIM IR.