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Research Article

Dynamic Modelling under Uncertainty: The Case of Trypanosoma brucei Energy Metabolism

  • Fiona Achcar,

    Affiliations: Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, Groningen Bioinformatics Centre, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, The Netherlands

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  • Eduard J. Kerkhoven,

    Affiliation: Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

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  • The SilicoTryp Consortium,

    Membership of The SilicoTryp Consortium is provided in the Acknowledgments.

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  • Barbara M. Bakker,

    Affiliation: Department of Liver, Digestive and Metabolic Diseases, University Medical Centre Groningen, University of Groningen, The Netherlands

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  • Michael P. Barrett,

    Affiliation: Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

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  • Rainer Breitling mail

    Rainer.Breitling@glasgow.ac.uk

    Affiliations: Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, Groningen Bioinformatics Centre, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, The Netherlands

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  • Published: January 19, 2012
  • DOI: 10.1371/journal.pcbi.1002352

About the Authors

Fiona Achcar, Rainer Breitling
Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
Fiona Achcar, Rainer Breitling
Groningen Bioinformatics Centre, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, The Netherlands
Eduard J. Kerkhoven, Michael P. Barrett
Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
Barbara M. Bakker
Department of Liver, Digestive and Metabolic Diseases, University Medical Centre Groningen, University of Groningen, The Netherlands

Corresponding Author

Email: Rainer.Breitling@glasgow.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: FA RB. Performed the experiments: FA. Analyzed the data: FA EJK BMB MPB RB. Contributed reagents/materials/analysis tools: FA RB. Wrote the paper: FA EJK BMB MPB RB.