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Research Article

A Race between Tumor Immunoescape and Genome Maintenance Selects for Optimum Levels of (epi)genetic Instability

  • Shingo Iwami equal contributor,

    equal contributor Contributed equally to this work with: Shingo Iwami, Hiroshi Haeno

    Affiliation: PRESTO, Japan Science and Technology Agency, Graduate School of Mathematical Sciences, The University of Tokyo, Institute for Virus Research, Kyoto University, Kyoto, Japan

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  • Hiroshi Haeno equal contributor,

    equal contributor Contributed equally to this work with: Shingo Iwami, Hiroshi Haeno

    Affiliation: Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, and Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America

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  • Franziska Michor mail

    michor@jimmy.harvard.edu

    Affiliation: Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, and Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America

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  • Published: February 16, 2012
  • DOI: 10.1371/journal.pcbi.1002370

About the Authors

Shingo Iwami
PRESTO, Japan Science and Technology Agency, Graduate School of Mathematical Sciences, The University of Tokyo, Institute for Virus Research, Kyoto University, Kyoto, Japan
Hiroshi Haeno, Franziska Michor
Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, and Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America

Corresponding Author

Email: michor@jimmy.harvard.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SI HH FM. Performed the experiments: SI HH. Analyzed the data: SI HH. Contributed reagents/materials/analysis tools: SI HH FM. Wrote the paper: SI HH FM.