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Research Article

Modeling Cortisol Dynamics in the Neuro-endocrine Axis Distinguishes Normal, Depression, and Post-traumatic Stress Disorder (PTSD) in Humans

  • K. Sriram,

    Affiliations: Institute of Collaborative Biotechnologies, University of California, Santa Barbara, California, United States of America, Department of Chemical Engineering, University of California, Santa Barbara, California, United States of America

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  • Maria Rodriguez-Fernandez,

    Affiliations: Institute of Collaborative Biotechnologies, University of California, Santa Barbara, California, United States of America, Department of Chemical Engineering, University of California, Santa Barbara, California, United States of America

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  • Francis J. Doyle III mail

    doyle@engineering.ucsb.edu

    Affiliations: Institute of Collaborative Biotechnologies, University of California, Santa Barbara, California, United States of America, Department of Chemical Engineering, University of California, Santa Barbara, California, United States of America

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  • Published: February 16, 2012
  • DOI: 10.1371/journal.pcbi.1002379

About the Authors

K. Sriram, Maria Rodriguez-Fernandez, Francis J. Doyle III
Institute of Collaborative Biotechnologies, University of California, Santa Barbara, California, United States of America
K. Sriram, Maria Rodriguez-Fernandez, Francis J. Doyle III
Department of Chemical Engineering, University of California, Santa Barbara, California, United States of America

Corresponding Author

Email: doyle@engineering.ucsb.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: FJD KS. Performed the experiments: KS MRF. Analyzed the data: FJD KS MRF. Wrote the paper: FJD KS MRF.