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Research Article

On the Use of Gene Ontology Annotations to Assess Functional Similarity among Orthologs and Paralogs: A Short Report

  • Paul D. Thomas mail,

    go-discuss@lists.stanford.edu

    Affiliation: Division of Bioinformatics, Department of Preventive Medicine, University of Southern California, Los Angeles, California, United States of America

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  • Valerie Wood,

    Affiliation: Cambridge Systems Biology Centre and Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom

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  • Christopher J. Mungall,

    Affiliation: Genomics Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America

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  • Suzanna E. Lewis,

    Affiliation: Genomics Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America

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  • Judith A. Blake,

    Affiliation: Bioinformatics and Computational Biology, The Jackson Laboratory, Bar Harbor, Maine, United States of America

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  • on behalf of the Gene Ontology Consortium
  • Published: February 16, 2012
  • DOI: 10.1371/journal.pcbi.1002386

About the Authors

Paul D. Thomas
Division of Bioinformatics, Department of Preventive Medicine, University of Southern California, Los Angeles, California, United States of America
Valerie Wood
Cambridge Systems Biology Centre and Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom
Christopher J. Mungall, Suzanna E. Lewis
Genomics Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America
Judith A. Blake
Bioinformatics and Computational Biology, The Jackson Laboratory, Bar Harbor, Maine, United States of America

Corresponding Author

Email: go-discuss@lists.stanford.edu

Competing Interests

PDT, VW and JAB are funded in part by grants to maintain model organism databases.

Author Contributions

Conceived and designed the experiments: PDT VW. Performed the experiments: PDT VW CJM. Analyzed the data: PDT VW CJM SEL JAB. Wrote the paper: PDT VW SEL JAB.