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Research Article

A Self-Organizing State-Space-Model Approach for Parameter Estimation in Hodgkin-Huxley-Type Models of Single Neurons

  • Dimitrios V. Vavoulis mail,

    Dimitris.Vavoulis@dcs.warwick.ac.uk (DVV); Jianfeng.Feng@warwick.ac.uk (JF)

    Affiliation: Department of Computer Science, University of Warwick, Coventry, United Kingdom

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  • Volko A. Straub,

    Affiliation: Department of Cell Physiology and Pharmacology, University of Leicester, Leicester, United Kingdom

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  • John A. D. Aston,

    Affiliation: Department of Statistics, University of Warwick, Coventry, United Kingdom

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  • Jianfeng Feng mail

    Dimitris.Vavoulis@dcs.warwick.ac.uk (DVV); Jianfeng.Feng@warwick.ac.uk (JF)

    Affiliations: Department of Computer Science, University of Warwick, Coventry, United Kingdom, Centre for Computational Systems Biology, Fudan University, Shanghai, PR China

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  • Published: March 01, 2012
  • DOI: 10.1371/journal.pcbi.1002401

About the Authors

Dimitrios V. Vavoulis, Jianfeng Feng
Department of Computer Science, University of Warwick, Coventry, United Kingdom
Volko A. Straub
Department of Cell Physiology and Pharmacology, University of Leicester, Leicester, United Kingdom
John A. D. Aston
Department of Statistics, University of Warwick, Coventry, United Kingdom
Jianfeng Feng
Centre for Computational Systems Biology, Fudan University, Shanghai, PR China

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DVV VAS JADA JF. Performed the experiments: DVV VAS. Analyzed the data: DVV VAS. Contributed reagents/materials/analysis tools: DVV VAS JF. Wrote the paper: DVV VAS JADA JF.