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Research Article

Exploring the Evolution of Novel Enzyme Functions within Structurally Defined Protein Superfamilies

  • Nicholas Furnham mail,

    nickf@ebi.ac.uk

    Affiliation: EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom

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  • Ian Sillitoe,

    Affiliation: Institute of Structural and Molecular Biology, University College London, Darwin Building, London, United Kingdom

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  • Gemma L. Holliday,

    Affiliation: EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom

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  • Alison L. Cuff,

    Affiliation: Institute of Structural and Molecular Biology, University College London, Darwin Building, London, United Kingdom

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  • Roman A. Laskowski,

    Affiliation: EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom

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  • Christine A. Orengo,

    Affiliation: Institute of Structural and Molecular Biology, University College London, Darwin Building, London, United Kingdom

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  • Janet M. Thornton

    Affiliation: EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom

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  • Published: March 01, 2012
  • DOI: 10.1371/journal.pcbi.1002403

About the Authors

Nicholas Furnham, Gemma L. Holliday, Roman A. Laskowski, Janet M. Thornton
EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
Ian Sillitoe, Alison L. Cuff, Christine A. Orengo
Institute of Structural and Molecular Biology, University College London, Darwin Building, London, United Kingdom

Corresponding Author

Email: nickf@ebi.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NF CAO JMT. Performed the experiments: NF IS. Analyzed the data: NF GLH ALC. Contributed reagents/materials/analysis tools: RAL. Wrote the paper: NF RAL CAO JMT.