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Research Article

Network Evolution: Rewiring and Signatures of Conservation in Signaling

  • Mark G. F. Sun equal contributor,

    equal contributor Contributed equally to this work with: Mark G. F. Sun, Martin Sikora

    Affiliation: Department of Computer Science, University of Toronto, Toronto, Canada

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  • Martin Sikora equal contributor,

    equal contributor Contributed equally to this work with: Mark G. F. Sun, Martin Sikora

    Affiliations: Banting and Best Department of Medical Research, University of Toronto, Toronto, Canada, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Canada, Institut de Biologia Evolutiva (UPF-CSIC), CEXS-UPF-PRBB, Barcelona, Spain

    Current address: Department of Genetics, Stanford University School of Medicine, Stanford, California, United States of America.

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  • Michael Costanzo,

    Affiliations: Banting and Best Department of Medical Research, University of Toronto, Toronto, Canada, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Canada

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  • Charles Boone,

    Affiliations: Banting and Best Department of Medical Research, University of Toronto, Toronto, Canada, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Canada

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  • Philip M. Kim mail

    pi@kimlab.org

    Affiliations: Department of Computer Science, University of Toronto, Toronto, Canada, Banting and Best Department of Medical Research, University of Toronto, Toronto, Canada, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Canada

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  • Published: March 15, 2012
  • DOI: 10.1371/journal.pcbi.1002411

About the Authors

Mark G. F. Sun, Philip M. Kim
Department of Computer Science, University of Toronto, Toronto, Canada
Martin Sikora, Michael Costanzo, Charles Boone, Philip M. Kim
Banting and Best Department of Medical Research, University of Toronto, Toronto, Canada
Martin Sikora, Michael Costanzo, Charles Boone, Philip M. Kim
Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Canada
Martin Sikora
Institut de Biologia Evolutiva (UPF-CSIC), CEXS-UPF-PRBB, Barcelona, Spain
Philip M. Kim
Department of Molecular Genetics, University of Toronto, Toronto, Canada

Corresponding Author

Email: pi@kimlab.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MGFS MS PMK. Performed the experiments: MGFS MS. Analyzed the data: MGFS MS PMK. Contributed reagents/materials/analysis tools: MGFS MS. Wrote the paper: MGFS MC CB PMK.