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Research Article

Living on Three Time Scales: The Dynamics of Plasma Cell and Antibody Populations Illustrated for Hepatitis A Virus

  • Mathieu Andraud mail,

    mathieu.andraud@ua.ac.be

    Affiliation: Centre for Health Economics Research and Modelling of Infectious Diseases (CHERMID), Vaccine & Infectious Disease Institute (VAXINFECTIO), University of Antwerp, Antwerp, Belgium

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  • Olivier Lejeune,

    Affiliations: Centre for Health Economics Research and Modelling of Infectious Diseases (CHERMID), Vaccine & Infectious Disease Institute (VAXINFECTIO), University of Antwerp, Antwerp, Belgium, The SYMBIOS Center, Division of Mathematics, University of Dundee, Dundee, United Kingdom

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  • Jammbe Z. Musoro,

    Affiliations: Interuniversity Institute of Biostatistics and Statistical Bioinformatics, Hasselt University, Diepenbeek, Belgium, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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  • Benson Ogunjimi,

    Affiliation: Centre for Health Economics Research and Modelling of Infectious Diseases (CHERMID), Vaccine & Infectious Disease Institute (VAXINFECTIO), University of Antwerp, Antwerp, Belgium

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  • Philippe Beutels,

    Affiliation: Centre for Health Economics Research and Modelling of Infectious Diseases (CHERMID), Vaccine & Infectious Disease Institute (VAXINFECTIO), University of Antwerp, Antwerp, Belgium

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  • Niel Hens

    Affiliations: Centre for Health Economics Research and Modelling of Infectious Diseases (CHERMID), Vaccine & Infectious Disease Institute (VAXINFECTIO), University of Antwerp, Antwerp, Belgium, Interuniversity Institute of Biostatistics and Statistical Bioinformatics, Hasselt University, Diepenbeek, Belgium

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  • Published: March 01, 2012
  • DOI: 10.1371/journal.pcbi.1002418

About the Authors

Mathieu Andraud, Olivier Lejeune, Benson Ogunjimi, Philippe Beutels, Niel Hens
Centre for Health Economics Research and Modelling of Infectious Diseases (CHERMID), Vaccine & Infectious Disease Institute (VAXINFECTIO), University of Antwerp, Antwerp, Belgium
Olivier Lejeune
The SYMBIOS Center, Division of Mathematics, University of Dundee, Dundee, United Kingdom
Jammbe Z. Musoro, Niel Hens
Interuniversity Institute of Biostatistics and Statistical Bioinformatics, Hasselt University, Diepenbeek, Belgium
Jammbe Z. Musoro
Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

Corresponding Author

Email: mathieu.andraud@ua.ac.be

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MA OL PB NH. Performed the experiments: MA OL JZM NH. Analyzed the data: MA OL JZM NH. Wrote the paper: MA OL JZM BO PB NH. Interpreted the results: MA OL JZM BO PB NH.