A Common Model for Cytokine Receptor Activation: Combined Scissor-Like Rotation and Self-Rotation of Receptor Dimer Induced by Class I Cytokine

Xiaodong Pang; Huan-Xiang Zhou

doi:10.1371/journal.pcbi.1002427

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Open Access

Peer-reviewed

Research Article

A Common Model for Cytokine Receptor Activation: Combined Scissor-Like Rotation and Self-Rotation of Receptor Dimer Induced by Class I Cytokine

Xiaodong Pang,

Affiliations Department of Physics, Florida State University, Tallahassee, Florida, United States of America, Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida, United States of America
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Huan-Xiang Zhou

* E-mail: hzhou4@fsu.edu

Affiliations Department of Physics, Florida State University, Tallahassee, Florida, United States of America, Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida, United States of America
⨯

A Common Model for Cytokine Receptor Activation: Combined Scissor-Like Rotation and Self-Rotation of Receptor Dimer Induced by Class I Cytokine

Xiaodong Pang,
Huan-Xiang Zhou

Published: March 8, 2012
https://doi.org/10.1371/journal.pcbi.1002427

About the Authors

Xiaodong Pang

Affiliations Department of Physics, Florida State University, Tallahassee, Florida, United States of America, Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida, United States of America

Huan-Xiang Zhou

* E-mail: hzhou4@fsu.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HXZ. Performed the experiments: XP. Analyzed the data: XP. Contributed reagents/materials/analysis tools: XP. Wrote the paper: XP HXZ.

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Cytokine receptors
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Cytokines
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Cell membranes
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Partial agonists
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Membrane receptor signaling
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Dimers
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Intracellular receptors
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Erythropoietin
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