Advertisement
Research Article

Automatic Filtering and Substantiation of Drug Safety Signals

  • Anna Bauer-Mehren,

    Affiliation: Research Programme on Biomedical Informatics (GRIB), IMIM-Hospital del Mar Research Institute, DCEX, Universitat Pompeu Fabra, Barcelona, Spain

    X
  • Erik M. van Mullingen,

    Affiliation: Erasmus University Medical Center, Rotterdam, The Netherlands

    X
  • Paul Avillach,

    Affiliations: LESIM-ISPED, Université de Bordeaux, Bordeaux, France, LERTIM, EA 3283, Faculté de Médecine, Université de Aix-Marseille, Marseille, France

    X
  • María del Carmen Carrascosa,

    Affiliation: Research Programme on Biomedical Informatics (GRIB), IMIM-Hospital del Mar Research Institute, DCEX, Universitat Pompeu Fabra, Barcelona, Spain

    X
  • Ricard Garcia-Serna,

    Affiliation: Research Programme on Biomedical Informatics (GRIB), IMIM-Hospital del Mar Research Institute, DCEX, Universitat Pompeu Fabra, Barcelona, Spain

    X
  • Janet Piñero,

    Affiliation: Research Programme on Biomedical Informatics (GRIB), IMIM-Hospital del Mar Research Institute, DCEX, Universitat Pompeu Fabra, Barcelona, Spain

    X
  • Bharat Singh,

    Affiliation: Erasmus University Medical Center, Rotterdam, The Netherlands

    X
  • Pedro Lopes,

    Affiliation: DETI/IEETA, Universidade de Aveiro, Aveiro, Portugal

    X
  • José L. Oliveira,

    Affiliation: DETI/IEETA, Universidade de Aveiro, Aveiro, Portugal

    X
  • Gayo Diallo,

    Affiliation: LESIM-ISPED, Université de Bordeaux, Bordeaux, France

    X
  • Ernst Ahlberg Helgee,

    Affiliation: AstraZeneca, Mölndal, Sweden

    X
  • Scott Boyer,

    Affiliation: AstraZeneca, Mölndal, Sweden

    X
  • Jordi Mestres,

    Affiliation: Research Programme on Biomedical Informatics (GRIB), IMIM-Hospital del Mar Research Institute, DCEX, Universitat Pompeu Fabra, Barcelona, Spain

    X
  • Ferran Sanz,

    Affiliation: Research Programme on Biomedical Informatics (GRIB), IMIM-Hospital del Mar Research Institute, DCEX, Universitat Pompeu Fabra, Barcelona, Spain

    X
  • Jan A. Kors,

    Affiliation: Erasmus University Medical Center, Rotterdam, The Netherlands

    X
  • Laura I. Furlong mail

    lfurlong@imim.es

    Affiliation: Research Programme on Biomedical Informatics (GRIB), IMIM-Hospital del Mar Research Institute, DCEX, Universitat Pompeu Fabra, Barcelona, Spain

    X
  • Published: April 05, 2012
  • DOI: 10.1371/journal.pcbi.1002457

About the Authors

Anna Bauer-Mehren, María del Carmen Carrascosa, Ricard Garcia-Serna, Janet Piñero, Jordi Mestres, Ferran Sanz, Laura I. Furlong
Research Programme on Biomedical Informatics (GRIB), IMIM-Hospital del Mar Research Institute, DCEX, Universitat Pompeu Fabra, Barcelona, Spain
Erik M. van Mullingen, Bharat Singh, Jan A. Kors
Erasmus University Medical Center, Rotterdam, The Netherlands
Paul Avillach, Gayo Diallo
LESIM-ISPED, Université de Bordeaux, Bordeaux, France
Paul Avillach
LERTIM, EA 3283, Faculté de Médecine, Université de Aix-Marseille, Marseille, France
Pedro Lopes, José L. Oliveira
DETI/IEETA, Universidade de Aveiro, Aveiro, Portugal
Ernst Ahlberg Helgee, Scott Boyer
AstraZeneca, Mölndal, Sweden

Corresponding Author

Email: lfurlong@imim.es

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: FS LIF. Performed the experiments: ABM LIF. Analyzed the data: ABM LIF. Wrote the paper: ABM LIF. Contributed the drug metabolism data: EAH SB. Designed and Developed the cglAlertService web services: MCC RGS JM. Designed and developed the adrPathService web services and the ADR-S workflow: ABM LIF. Designed and developed the ADR-FM workflow: PA GD. Designed and developed the ADR-FD workflow: EMvM BS JAK. Contributed to the overall development of web services, schema and workflows: PL JLO. Performed the statistical analysis: ABM JP.