About the Authors

Anna Bauer-Mehren

Affiliation Research Programme on Biomedical Informatics (GRIB), IMIM-Hospital del Mar Research Institute, DCEX, Universitat Pompeu Fabra, Barcelona, Spain

Erik M. van Mullingen

Affiliation Erasmus University Medical Center, Rotterdam, The Netherlands

Paul Avillach

Affiliations LESIM-ISPED, Université de Bordeaux, Bordeaux, France, LERTIM, EA 3283, Faculté de Médecine, Université de Aix-Marseille, Marseille, France

María del Carmen Carrascosa

Affiliation Research Programme on Biomedical Informatics (GRIB), IMIM-Hospital del Mar Research Institute, DCEX, Universitat Pompeu Fabra, Barcelona, Spain

Ricard Garcia-Serna

Affiliation Research Programme on Biomedical Informatics (GRIB), IMIM-Hospital del Mar Research Institute, DCEX, Universitat Pompeu Fabra, Barcelona, Spain

Janet Piñero

Affiliation Research Programme on Biomedical Informatics (GRIB), IMIM-Hospital del Mar Research Institute, DCEX, Universitat Pompeu Fabra, Barcelona, Spain

Bharat Singh

Affiliation Erasmus University Medical Center, Rotterdam, The Netherlands

Pedro Lopes

Affiliation DETI/IEETA, Universidade de Aveiro, Aveiro, Portugal

José L. Oliveira

Affiliation DETI/IEETA, Universidade de Aveiro, Aveiro, Portugal

Gayo Diallo

Affiliation LESIM-ISPED, Université de Bordeaux, Bordeaux, France

Ernst Ahlberg Helgee

Affiliation AstraZeneca, Mölndal, Sweden

Scott Boyer

Affiliation AstraZeneca, Mölndal, Sweden

Jordi Mestres

Affiliation Research Programme on Biomedical Informatics (GRIB), IMIM-Hospital del Mar Research Institute, DCEX, Universitat Pompeu Fabra, Barcelona, Spain

Ferran Sanz

Affiliation Research Programme on Biomedical Informatics (GRIB), IMIM-Hospital del Mar Research Institute, DCEX, Universitat Pompeu Fabra, Barcelona, Spain

Jan A. Kors

Affiliation Erasmus University Medical Center, Rotterdam, The Netherlands

Laura I. Furlong

lfurlong@imim.es

Affiliation Research Programme on Biomedical Informatics (GRIB), IMIM-Hospital del Mar Research Institute, DCEX, Universitat Pompeu Fabra, Barcelona, Spain

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: FS LIF. Performed the experiments: ABM LIF. Analyzed the data: ABM LIF. Wrote the paper: ABM LIF. Contributed the drug metabolism data: EAH SB. Designed and Developed the cglAlertService web services: MCC RGS JM. Designed and developed the adrPathService web services and the ADR-S workflow: ABM LIF. Designed and developed the ADR-FM workflow: PA GD. Designed and developed the ADR-FD workflow: EMvM BS JAK. Contributed to the overall development of web services, schema and workflows: PL JLO. Performed the statistical analysis: ABM JP.