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Research Article

Genome-Scale Modeling of Light-Driven Reductant Partitioning and Carbon Fluxes in Diazotrophic Unicellular Cyanobacterium Cyanothece sp. ATCC 51142

  • Trang T. Vu equal contributor,

    equal contributor Contributed equally to this work with: Trang T. Vu, Sergey M. Stolyar

    Affiliation: Department of Chemical and Biological Engineering, University of Wisconsin- Madison, Madison, Wisconsin, United States of America

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  • Sergey M. Stolyar equal contributor,

    equal contributor Contributed equally to this work with: Trang T. Vu, Sergey M. Stolyar

    Affiliation: Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America

    X
  • Grigoriy E. Pinchuk,

    Affiliation: Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America

    X
  • Eric A. Hill,

    Affiliation: Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America

    X
  • Leo A. Kucek,

    Affiliation: Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America

    X
  • Roslyn N. Brown,

    Affiliation: Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America

    X
  • Mary S. Lipton,

    Affiliation: Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America

    X
  • Andrei Osterman,

    Affiliation: Burnham Institute for Medical Research, La Jolla, California, United States of America

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  • Jim K. Fredrickson,

    Affiliation: Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America

    X
  • Allan E. Konopka,

    Affiliation: Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America

    X
  • Alexander S. Beliaev mail,

    alex.beliaev@pnnl.gov (ASB); reed@engr.wisc.edu (JLR)

    Affiliation: Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America

    X
  • Jennifer L. Reed mail

    alex.beliaev@pnnl.gov (ASB); reed@engr.wisc.edu (JLR)

    Affiliation: Department of Chemical and Biological Engineering, University of Wisconsin- Madison, Madison, Wisconsin, United States of America

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  • Published: April 05, 2012
  • DOI: 10.1371/journal.pcbi.1002460

About the Authors

Trang T. Vu, Jennifer L. Reed
Department of Chemical and Biological Engineering, University of Wisconsin- Madison, Madison, Wisconsin, United States of America
Sergey M. Stolyar, Grigoriy E. Pinchuk, Eric A. Hill, Leo A. Kucek, Roslyn N. Brown, Mary S. Lipton, Jim K. Fredrickson, Allan E. Konopka, Alexander S. Beliaev
Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America
Andrei Osterman
Burnham Institute for Medical Research, La Jolla, California, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TV SMS GEP JKF AEK ASB JLR. Performed the experiments: SMS GEP EAH LAK RNB. Analyzed the data: TV SMS GEP ASB JLR. Contributed reagents/materials/analysis tools: ALO RNB MSL. Wrote the paper: TV SMS GEP JKF AEK ASB JLR. Performed the computational simulations: TV.