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Research Article

Ligand-Dependent Conformations and Dynamics of the Serotonin 5-HT2A Receptor Determine Its Activation and Membrane-Driven Oligomerization Properties

  • Jufang Shan,

    Affiliation: Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York, New York, United States of America

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  • George Khelashvili,

    Affiliation: Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York, New York, United States of America

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  • Sayan Mondal,

    Affiliation: Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York, New York, United States of America

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  • Ernest L. Mehler,

    Affiliation: Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York, New York, United States of America

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  • Harel Weinstein mail

    haw2002@med.cornell.edu

    Affiliations: Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York, New York, United States of America, The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Medical College of Cornell University, New York, New York, United States of America

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  • Published: April 19, 2012
  • DOI: 10.1371/journal.pcbi.1002473

About the Authors

Jufang Shan, George Khelashvili, Sayan Mondal, Ernest L. Mehler, Harel Weinstein
Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York, New York, United States of America
Harel Weinstein
The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Medical College of Cornell University, New York, New York, United States of America

Corresponding Author

Email: haw2002@med.cornell.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JS GK SM HW. Performed the experiments: JS SM. Analyzed the data: JS GK SM ELM HW. Contributed reagents/materials/analysis tools: SM ELM. Wrote the paper: JS GK SM ELM HW.