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Research Article

Establishment and Validation of Computational Model for MT1-MMP Dependent ECM Degradation and Intervention Strategies

  • Daisuke Hoshino,

    Affiliation: Division of Cancer Cell Research, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo, Japan

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  • Naohiko Koshikawa,

    Affiliation: Division of Cancer Cell Research, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo, Japan

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  • Takashi Suzuki,

    Affiliations: Division of Mathematical Science, Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka, Japan, JST, CREST, Chiyoda-ku, Tokyo, Japan

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  • Vito Quaranta,

    Affiliation: Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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  • Alissa M. Weaver,

    Affiliation: Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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  • Motoharu Seiki mail,

    mseiki@ims.u-tokyo.ac.jp

    Affiliations: Division of Cancer Cell Research, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo, Japan, JST, CREST, Chiyoda-ku, Tokyo, Japan

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  • Kazuhisa Ichikawa

    Affiliations: JST, CREST, Chiyoda-ku, Tokyo, Japan, Division of Mathematical Oncology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo, Japan

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  • Published: April 12, 2012
  • DOI: 10.1371/journal.pcbi.1002479

About the Authors

Daisuke Hoshino, Naohiko Koshikawa, Motoharu Seiki
Division of Cancer Cell Research, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo, Japan
Takashi Suzuki
Division of Mathematical Science, Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka, Japan
Takashi Suzuki, Motoharu Seiki, Kazuhisa Ichikawa
JST, CREST, Chiyoda-ku, Tokyo, Japan
Vito Quaranta, Alissa M. Weaver
Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
Kazuhisa Ichikawa
Division of Mathematical Oncology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo, Japan

Corresponding Author

Email: mseiki@ims.u-tokyo.ac.jp

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DH NK TS MS KI. Performed the experiments: DH. Analyzed the data: DH KI. Contributed reagents/materials/analysis tools: DH VQ AW. Wrote the paper: DH KI.