Mapping the Environmental Fitness Landscape of a Synthetic Gene Circuit

Dmitry Nevozhay; Rhys M. Adams; Elizabeth Van Itallie; Matthew R. Bennett; Gábor Balázsi

doi:10.1371/journal.pcbi.1002480

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Open Access

Peer-reviewed

Research Article

Mapping the Environmental Fitness Landscape of a Synthetic Gene Circuit

Dmitry Nevozhay ,

Contributed equally to this work with: Dmitry Nevozhay, Rhys M. Adams

Affiliation Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Rhys M. Adams ,

Contributed equally to this work with: Dmitry Nevozhay, Rhys M. Adams

Affiliation Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Elizabeth Van Itallie,

Affiliation Department of Biochemistry and Cell Biology and Institute of Biosciences and Bioengineering, Rice University, Houston, Texas, United States of America
⨯
Matthew R. Bennett,

Affiliation Department of Biochemistry and Cell Biology and Institute of Biosciences and Bioengineering, Rice University, Houston, Texas, United States of America
⨯
Gábor Balázsi

* E-mail: gbalazsi@mdanderson.org

Affiliation Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯

Mapping the Environmental Fitness Landscape of a Synthetic Gene Circuit

Dmitry Nevozhay,
Rhys M. Adams,
Elizabeth Van Itallie,
Matthew R. Bennett,
Gábor Balázsi

Published: April 12, 2012
https://doi.org/10.1371/journal.pcbi.1002480

About the Authors

Dmitry Nevozhay

Contributed equally to this work with: Dmitry Nevozhay, Rhys M. Adams

Affiliation Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

Rhys M. Adams

Contributed equally to this work with: Dmitry Nevozhay, Rhys M. Adams

Affiliation Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

Elizabeth Van Itallie

Affiliation Department of Biochemistry and Cell Biology and Institute of Biosciences and Bioengineering, Rice University, Houston, Texas, United States of America

Matthew R. Bennett

Affiliation Department of Biochemistry and Cell Biology and Institute of Biosciences and Bioengineering, Rice University, Houston, Texas, United States of America

Gábor Balázsi

* E-mail: gbalazsi@mdanderson.org

Affiliation Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DN RMA GB. Performed the experiments: DN RMA EVI MRB. Analyzed the data: RMA. Contributed reagents/materials/analysis tools: DN RMA. Wrote the paper: DN RMA GB.

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Gene expression
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Cell cycle and cell division
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Synthetic genetic networks
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Antibiotics
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Toxicity
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Gene regulatory networks
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Phenotypes
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Population growth
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