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Research Article

Microarray Analysis of LTR Retrotransposon Silencing Identifies Hdac1 as a Regulator of Retrotransposon Expression in Mouse Embryonic Stem Cells

  • Judith Reichmann equal contributor,

    equal contributor Contributed equally to this work with: Judith Reichmann, James H. Crichton

    Affiliation: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom

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  • James H. Crichton equal contributor,

    equal contributor Contributed equally to this work with: Judith Reichmann, James H. Crichton

    Affiliation: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom

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  • Monika J. Madej,

    Affiliation: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom

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  • Mary Taggart,

    Affiliation: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom

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  • Philippe Gautier,

    Affiliation: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom

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  • Jose Luis Garcia-Perez,

    Affiliation: GENYO, Pfizer-University of Granada-Andalusian Government-Centre for Genomics and Oncological Research, Granada, Spain

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  • Richard R. Meehan,

    Affiliation: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom

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  • Ian R. Adams mail

    Ian.Adams@igmm.ed.ac.uk

    Affiliation: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom

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  • Published: April 26, 2012
  • DOI: 10.1371/journal.pcbi.1002486

About the Authors

Judith Reichmann, James H. Crichton, Monika J. Madej, Mary Taggart, Philippe Gautier, Richard R. Meehan, Ian R. Adams
MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom
Jose Luis Garcia-Perez
GENYO, Pfizer-University of Granada-Andalusian Government-Centre for Genomics and Oncological Research, Granada, Spain

Corresponding Author

Email: Ian.Adams@igmm.ed.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JR PG JLG-P RRM IRA. Performed the experiments: JR JHC MJM MT PG IRA. Analyzed the data: JR JHC MJM PG IRA. Contributed reagents/materials/analysis tools: IRA. Wrote the paper: JLG-P RRM IRA.