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Research Article

Prediction of Drug-Target Interactions and Drug Repositioning via Network-Based Inference

  • Feixiong Cheng equal contributor,

    equal contributor Contributed equally to this work with: Feixiong Cheng, Chuang Liu

    Affiliation: Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, China

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  • Chuang Liu equal contributor,

    equal contributor Contributed equally to this work with: Feixiong Cheng, Chuang Liu

    Affiliation: School of Business, East China University of Science and Technology, Shanghai, China

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  • Jing Jiang,

    Affiliation: Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, China

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  • Weiqiang Lu,

    Affiliation: Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, China

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  • Weihua Li,

    Affiliation: Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, China

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  • Guixia Liu,

    Affiliation: Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, China

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  • Weixing Zhou mail,

    wxzhou@ecust.edu.cn (WZ); huangjin@ecust.edu.cn (JH); ytang234@ecust.edu.cn (YT)

    Affiliation: School of Business, East China University of Science and Technology, Shanghai, China

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  • Jin Huang mail,

    wxzhou@ecust.edu.cn (WZ); huangjin@ecust.edu.cn (JH); ytang234@ecust.edu.cn (YT)

    Affiliation: Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, China

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  • Yun Tang mail

    wxzhou@ecust.edu.cn (WZ); huangjin@ecust.edu.cn (JH); ytang234@ecust.edu.cn (YT)

    Affiliation: Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, China

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  • Published: May 10, 2012
  • DOI: 10.1371/journal.pcbi.1002503

About the Authors

Feixiong Cheng, Jing Jiang, Weiqiang Lu, Weihua Li, Guixia Liu, Jin Huang, Yun Tang
Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, China
Chuang Liu, Weixing Zhou
School of Business, East China University of Science and Technology, Shanghai, China

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: F. Cheng, W. Zhou, Y. Tang. Performed the experiments: F. Cheng, C. Liu, J. Jiang, W. Lu, J. Huang. Analyzed the data: F. Cheng, C. Liu, W. Li, G. Liu, Y. Tang. Contributed reagents/materials/analysis tools: F. Cheng, Y. Tang. Wrote the paper: F. Cheng, C. Liu, Y. Tang.