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Research Article

Modeling HIV-1 Drug Resistance as Episodic Directional Selection

  • Ben Murrell,

    Affiliations: Biomedical Informatics Research Division, eHealth Research and Innovation Platform, Medical Research Council, Tygerberg, South Africa, Computer Science Division, Department of Mathematical Sciences, Stellenbosch University, Stellenbosch, South Africa

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  • Tulio de Oliveira,

    Affiliations: Africa Centre for Health and Population Studies, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa, Research Department of Infection and Population Health, University College London, London, United Kingdom

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  • Chris Seebregts,

    Affiliations: Biomedical Informatics Research Division, eHealth Research and Innovation Platform, Medical Research Council, Tygerberg, South Africa, School of Computer Science, University of KwaZulu-Natal, Durban, South Africa

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  • Sergei L. Kosakovsky Pond,

    Affiliation: Department of Medicine, University of California San Diego, San Diego, California, United States of America

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  • Konrad Scheffler mail,

    kscheffler@ucsd.edu

    Affiliations: Computer Science Division, Department of Mathematical Sciences, Stellenbosch University, Stellenbosch, South Africa, Department of Medicine, University of California San Diego, San Diego, California, United States of America

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  • on behalf of the Southern African Treatment and Resistance Network (SATuRN) Consortium
  • Published: May 10, 2012
  • DOI: 10.1371/journal.pcbi.1002507

About the Authors

Ben Murrell, Chris Seebregts
Biomedical Informatics Research Division, eHealth Research and Innovation Platform, Medical Research Council, Tygerberg, South Africa
Ben Murrell, Konrad Scheffler
Computer Science Division, Department of Mathematical Sciences, Stellenbosch University, Stellenbosch, South Africa
Tulio de Oliveira
Africa Centre for Health and Population Studies, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa
Tulio de Oliveira
Research Department of Infection and Population Health, University College London, London, United Kingdom
Chris Seebregts
School of Computer Science, University of KwaZulu-Natal, Durban, South Africa
Sergei L. Kosakovsky Pond, Konrad Scheffler
Department of Medicine, University of California San Diego, San Diego, California, United States of America

Corresponding Author

Email: kscheffler@ucsd.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BM SLKP KS. Performed the experiments: BM SLKP. Analyzed the data: BM SLKP KS. Wrote the paper: BM TdO CS SLKP KS.