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Research Article

Google Goes Cancer: Improving Outcome Prediction for Cancer Patients by Network-Based Ranking of Marker Genes

  • Christof Winter equal contributor mail,

    equal contributor Contributed equally to this work with: Christof Winter, Glen Kristiansen, Stephan Kersting

    winter@biotec.tu-dresden.de

    Affiliation: Department of Bioinformatics, Biotechnology Center, Technische Universität Dresden, Dresden, Germany

    X
  • Glen Kristiansen equal contributor,

    equal contributor Contributed equally to this work with: Christof Winter, Glen Kristiansen, Stephan Kersting

    Affiliation: Institute of Pathology, Universitätsspital Zürich, Zurich, Switzerland

    X
  • Stephan Kersting equal contributor,

    equal contributor Contributed equally to this work with: Christof Winter, Glen Kristiansen, Stephan Kersting

    Affiliation: Department of Visceral, Thoracic, and Vascular Surgery, University Hospital Carl Gustav Carus, Dresden, Germany

    X
  • Janine Roy,

    Affiliation: Department of Bioinformatics, Biotechnology Center, Technische Universität Dresden, Dresden, Germany

    X
  • Daniela Aust,

    Affiliation: Institute of Pathology, University Hospital Carl Gustav Carus, Dresden, Germany

    X
  • Thomas Knösel,

    Affiliation: Institute of Pathology, University of Jena, Jena, Germany

    X
  • Petra Rümmele,

    Affiliation: Institute of Pathology, University of Regensburg, Regensburg, Germany

    X
  • Beatrix Jahnke,

    Affiliation: Department of Visceral, Thoracic, and Vascular Surgery, University Hospital Carl Gustav Carus, Dresden, Germany

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  • Vera Hentrich,

    Affiliation: Department of Visceral, Thoracic, and Vascular Surgery, University Hospital Carl Gustav Carus, Dresden, Germany

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  • Felix Rückert,

    Affiliation: Department of Visceral, Thoracic, and Vascular Surgery, University Hospital Carl Gustav Carus, Dresden, Germany

    X
  • Marco Niedergethmann,

    Affiliation: Department of Surgery, University Hospital Mannheim, Mannheim, Germany

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  • Wilko Weichert,

    Affiliation: Department of Pathology, Charité, Berlin, Germany

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  • Marcus Bahra,

    Affiliation: Department of Surgery, Charité, Berlin, Germany

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  • Hans J. Schlitt,

    Affiliation: Department of Surgery, University Hospital Regensburg, Regensburg, Germany

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  • Utz Settmacher,

    Affiliation: Department of Surgery, University Hospital Jena, Jena, Germany

    X
  • Helmut Friess,

    Affiliation: Department of Surgery, Technische Universität München, München, Germany

    X
  • Markus Büchler,

    Affiliation: Department of Surgery, University of Heidelberg, Heidelberg, Germany

    X
  • Hans-Detlev Saeger,

    Affiliation: Department of Visceral, Thoracic, and Vascular Surgery, University Hospital Carl Gustav Carus, Dresden, Germany

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  • Michael Schroeder ,

    Affiliation: Department of Bioinformatics, Biotechnology Center, Technische Universität Dresden, Dresden, Germany

    These authors are joint senior authors on this work.

    X
  • Christian Pilarsky ,

    Affiliation: Department of Visceral, Thoracic, and Vascular Surgery, University Hospital Carl Gustav Carus, Dresden, Germany

    These authors are joint senior authors on this work.

    X
  • Robert Grützmann

    Affiliation: Department of Visceral, Thoracic, and Vascular Surgery, University Hospital Carl Gustav Carus, Dresden, Germany

    These authors are joint senior authors on this work.

    X
  • Published: May 17, 2012
  • DOI: 10.1371/journal.pcbi.1002511

About the Authors

Christof Winter, Janine Roy, Michael Schroeder
Department of Bioinformatics, Biotechnology Center, Technische Universität Dresden, Dresden, Germany
Glen Kristiansen
Institute of Pathology, Universitätsspital Zürich, Zurich, Switzerland
Stephan Kersting, Beatrix Jahnke, Vera Hentrich, Felix Rückert, Hans-Detlev Saeger, Christian Pilarsky, Robert Grützmann
Department of Visceral, Thoracic, and Vascular Surgery, University Hospital Carl Gustav Carus, Dresden, Germany
Daniela Aust
Institute of Pathology, University Hospital Carl Gustav Carus, Dresden, Germany
Thomas Knösel
Institute of Pathology, University of Jena, Jena, Germany
Petra Rümmele
Institute of Pathology, University of Regensburg, Regensburg, Germany
Marco Niedergethmann
Department of Surgery, University Hospital Mannheim, Mannheim, Germany
Wilko Weichert
Department of Pathology, Charité, Berlin, Germany
Marcus Bahra
Department of Surgery, Charité, Berlin, Germany
Hans J. Schlitt
Department of Surgery, University Hospital Regensburg, Regensburg, Germany
Utz Settmacher
Department of Surgery, University Hospital Jena, Jena, Germany
Helmut Friess
Department of Surgery, Technische Universität München, München, Germany
Markus Büchler
Department of Surgery, University of Heidelberg, Heidelberg, Germany

Corresponding Author

Email: winter@biotec.tu-dresden.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: C. Winter G. Kristiansen S. Kersting H. Saeger M. Schroeder C. Pilarsky R. Grützmann. Performed the experiments: C. Winter G. Kristiansen J. Roy D. Aust T. Knösel P. Rümmele B. Jahnke. Analyzed the data: C. Winter S. Kersting J. Roy M. Schroeder C. Pilarsky R. Grützmann. Contributed reagents/materials/analysis tools: V. Hentrich F. Rückert M. Niedergethmann W. Weichert M. Bahra H. Schlitt U. Settmacher H. Friess M. Büchler. Wrote the paper: C. Winter S. Kersting M. Schroeder C. Pilarsky R. Grützmann. Developed NetRank and the prognostic signatures: C. Winter. Evaluated the immunohistochemistry stainings: G. Kristiansen.