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Research Article

Resolving the Ortholog Conjecture: Orthologs Tend to Be Weakly, but Significantly, More Similar in Function than Paralogs

  • Adrian M. Altenhoff,

    Affiliations: ETH Zurich, Department of Computer Science, Zürich, Switzerland, Swiss Institute of Bioinformatics, Lausanne, Switzerland

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  • Romain A. Studer,

    Affiliations: Swiss Institute of Bioinformatics, Lausanne, Switzerland, Department of Ecology and Evolution, University of Lausanne, Lausanne, Switzerland, Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London, United Kingdom

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  • Marc Robinson-Rechavi,

    Affiliations: Swiss Institute of Bioinformatics, Lausanne, Switzerland, Department of Ecology and Evolution, University of Lausanne, Lausanne, Switzerland

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  • Christophe Dessimoz mail

    dessimoz@ebi.ac.uk

    Affiliations: ETH Zurich, Department of Computer Science, Zürich, Switzerland, Swiss Institute of Bioinformatics, Lausanne, Switzerland, EMBL-European Bioinformatics Institute, Hinxton, Cambridge, United Kingdom

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  • Published: May 17, 2012
  • DOI: 10.1371/journal.pcbi.1002514

About the Authors

Adrian M. Altenhoff, Christophe Dessimoz
ETH Zurich, Department of Computer Science, Zürich, Switzerland
Adrian M. Altenhoff, Romain A. Studer, Marc Robinson-Rechavi, Christophe Dessimoz
Swiss Institute of Bioinformatics, Lausanne, Switzerland
Romain A. Studer, Marc Robinson-Rechavi
Department of Ecology and Evolution, University of Lausanne, Lausanne, Switzerland
Romain A. Studer
Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London, United Kingdom
Christophe Dessimoz
EMBL-European Bioinformatics Institute, Hinxton, Cambridge, United Kingdom

Corresponding Author

Email: dessimoz@ebi.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AMA MRR CD. Performed the experiments: AMA RAS. Analyzed the data: AMA MRR CD. Contributed reagents/materials/analysis tools: AMA RAS MRR CD. Wrote the paper: AMA MRR CD.