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Research Article

A Two-Dimensional Model of the Colonic Crypt Accounting for the Role of the Basement Membrane and Pericryptal Fibroblast Sheath

  • Sara-Jane Dunn mail,

    sara-jane.dunn@microsoft.com

    Affiliations: Department of Computer Science, University of Oxford, Oxford, United Kingdom, Microsoft Research Ltd., Cambridge, United Kingdom

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  • Paul L. Appleton,

    Affiliation: College of Life Sciences, University of Dundee, Dundee, United Kingdom

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  • Scott A. Nelson,

    Affiliation: College of Life Sciences, University of Dundee, Dundee, United Kingdom

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  • Inke S. Näthke,

    Affiliation: College of Life Sciences, University of Dundee, Dundee, United Kingdom

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  • David J. Gavaghan,

    Affiliations: Department of Computer Science, University of Oxford, Oxford, United Kingdom, Oxford Centre for Integrative Systems Biology, Department of Biochemistry, Oxford, United Kingdom

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  • James M. Osborne

    Affiliations: Department of Computer Science, University of Oxford, Oxford, United Kingdom, Oxford Centre for Integrative Systems Biology, Department of Biochemistry, Oxford, United Kingdom

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  • Published: May 24, 2012
  • DOI: 10.1371/journal.pcbi.1002515

About the Authors

Sara-Jane Dunn, David J. Gavaghan, James M. Osborne
Department of Computer Science, University of Oxford, Oxford, United Kingdom
Sara-Jane Dunn
Microsoft Research Ltd., Cambridge, United Kingdom
Paul L. Appleton, Scott A. Nelson, Inke S. Näthke
College of Life Sciences, University of Dundee, Dundee, United Kingdom
David J. Gavaghan, James M. Osborne
Oxford Centre for Integrative Systems Biology, Department of Biochemistry, Oxford, United Kingdom

Corresponding Author

Email: sara-jane.dunn@microsoft.com

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SJD PLA SAN ISN DJG JMO. Performed the experiments: SJD PLA SAN. Analyzed the data: SJD PLA SAN. Contributed reagents/materials/analysis tools: SJD PLA SAN ISN DJG JMO. Wrote the paper: SJD PLA.