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Research Article

Reconstruction of Genome-Scale Active Metabolic Networks for 69 Human Cell Types and 16 Cancer Types Using INIT

  • Rasmus Agren equal contributor,

    equal contributor Contributed equally to this work with: Rasmus Agren, Sergio Bordel

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  • Sergio Bordel equal contributor,

    equal contributor Contributed equally to this work with: Rasmus Agren, Sergio Bordel

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  • Adil Mardinoglu ,

    These authors also contributed equally to this work.

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  • Natapol Pornputtapong ,

    These authors also contributed equally to this work.

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  • Intawat Nookaew,
  • Jens Nielsen mail

    nielsenj@chalmers.se

    Affiliation: Department of Chemical and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden

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  • Published: May 17, 2012
  • DOI: 10.1371/journal.pcbi.1002518

About the Authors

Jens Nielsen
Department of Chemical and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden

Corresponding Author

Email: nielsenj@chalmers.se

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Wrote the paper: RA SB IN JN. Conceived the project: JN. Supervised the work: SB JN. Developed the INIT algorithm: RA. Performed the comparative analysis between cancers and healthy cell types: SB. Performed the comparison of generated models with previously published models: AM. Developed the HMR database and generated the website for the Human Metabolic Atlas: NP. Performed analysis of the generated cell type models: IN. Edited the paper: RA SB AM NP IN JN.