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Research Article

Estimating the Fitness Cost of Escape from HLA Presentation in HIV-1 Protease and Reverse Transcriptase

  • Rafal Mostowy equal contributor mail,

    equal contributor Contributed equally to this work with: Rafal Mostowy, Roger D. Kouyos

    rafal.mostowy@gmail.com

    Affiliation: Institute for Integrative Biology, ETH Zurich, Zurich, Switzerland

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  • Roger D. Kouyos equal contributor,

    equal contributor Contributed equally to this work with: Rafal Mostowy, Roger D. Kouyos

    Affiliation: Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, United States of America

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  • Ilka Hoof,

    Affiliation: Theoretical Biology/Bioinformatics, Utrecht University, Utrecht, The Netherlands

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  • Trevor Hinkley,

    Affiliation: Institute for Integrative Biology, ETH Zurich, Zurich, Switzerland

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  • Mojgan Haddad,

    Affiliation: Monogram Biosciences, South San Francisco, California, Unites States of America

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  • Jeannette M. Whitcomb,

    Affiliation: Monogram Biosciences, South San Francisco, California, Unites States of America

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  • Christos J. Petropoulos,

    Affiliation: Monogram Biosciences, South San Francisco, California, Unites States of America

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  • Can Keşmir,

    Affiliation: Theoretical Biology/Bioinformatics, Utrecht University, Utrecht, The Netherlands

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  • Sebastian Bonhoeffer

    Affiliation: Institute for Integrative Biology, ETH Zurich, Zurich, Switzerland

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  • Published: May 24, 2012
  • DOI: 10.1371/journal.pcbi.1002525

About the Authors

Rafal Mostowy, Trevor Hinkley, Sebastian Bonhoeffer
Institute for Integrative Biology, ETH Zurich, Zurich, Switzerland
Roger D. Kouyos
Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, United States of America
Ilka Hoof, Can Keşmir
Theoretical Biology/Bioinformatics, Utrecht University, Utrecht, The Netherlands
Mojgan Haddad, Jeannette M. Whitcomb, Christos J. Petropoulos
Monogram Biosciences, South San Francisco, California, Unites States of America

Corresponding Author

Email: rafal.mostowy@gmail.com

Competing Interests

MH, JMW, and CJP are employed by Monogram Biosciences Inc. The remaining authors declare that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RM RDK IH CK SB. Performed the experiments: RM RDK IH. Analyzed the data: RM RDK IH CK SB. Contributed reagents/materials/analysis tools: MH JMW CJP SB. Wrote the paper: RM RDK SB. Developed software used in the analysis: TH IH.