Advertisement
Research Article

General Anesthetics Predicted to Block the GLIC Pore with Micromolar Affinity

  • David N. LeBard equal contributor,

    equal contributor Contributed equally to this work with: David N. LeBard, Jérôme Hénin

    Affiliation: Department of Chemistry and Institute for Computational Molecular Science, Temple University, Philadelphia, Pennsylvania, United States of America

    X
  • Jérôme Hénin equal contributor,

    equal contributor Contributed equally to this work with: David N. LeBard, Jérôme Hénin

    Affiliation: Laboratoire d'Ingénierie des Structures Macromoléculaires, CNRS and Aix-Marseille University, Marseille, France

    X
  • Roderic G. Eckenhoff,

    Affiliation: Department of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

    X
  • Michael L. Klein,

    Affiliation: Department of Chemistry and Institute for Computational Molecular Science, Temple University, Philadelphia, Pennsylvania, United States of America

    X
  • Grace Brannigan mail

    grace.brannigan@rutgers.edu

    Affiliation: Department of Physics and Center for Computational and Integrative Biology, Rutgers University-Camden, Camden, New Jersey, United States of America

    X
  • Published: May 31, 2012
  • DOI: 10.1371/journal.pcbi.1002532

About the Authors

David N. LeBard, Michael L. Klein
Department of Chemistry and Institute for Computational Molecular Science, Temple University, Philadelphia, Pennsylvania, United States of America
Jérôme Hénin
Laboratoire d'Ingénierie des Structures Macromoléculaires, CNRS and Aix-Marseille University, Marseille, France
Roderic G. Eckenhoff
Department of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
Grace Brannigan
Department of Physics and Center for Computational and Integrative Biology, Rutgers University-Camden, Camden, New Jersey, United States of America

Corresponding Author

Email: grace.brannigan@rutgers.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DNL JH GB. Performed the experiments: DNL. Analyzed the data: DNL JH GB. Contributed reagents/materials/analysis tools: JH GB. Wrote the paper: DNL JH RGE MLK GB.