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Research Article

Structural and Dynamic Requirements for Optimal Activity of the Essential Bacterial Enzyme Dihydrodipicolinate Synthase

  • C. F. Reboul,

    Affiliations: Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia, ARC Centre of Excellence in Structural and Functional Microbial Genomics, Monash University, Clayton, Victoria, Australia

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  • B. T. Porebski,

    Affiliation: Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia

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  • M. D. W. Griffin,

    Affiliation: Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria, Australia

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  • R. C. J. Dobson,

    Affiliations: Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria, Australia, Department of Biochemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia, Biomolecular Interaction Centre, and School of Biological Sciences, University of Canterbury, Christchurch, New Zealand

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  • M. A. Perugini,

    Affiliations: Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria, Australia, Department of Biochemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia

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  • J. A. Gerrard,

    Affiliation: Biomolecular Interaction Centre, and School of Biological Sciences, University of Canterbury, Christchurch, New Zealand

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  • A. M. Buckle mail

    ashley.buckle@monash.edu

    Affiliation: Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia

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  • Published: June 07, 2012
  • DOI: 10.1371/journal.pcbi.1002537

About the Authors

C. F. Reboul, B. T. Porebski, A. M. Buckle
Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
C. F. Reboul
ARC Centre of Excellence in Structural and Functional Microbial Genomics, Monash University, Clayton, Victoria, Australia
M. D. W. Griffin, R. C. J. Dobson, M. A. Perugini
Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria, Australia
R. C. J. Dobson, M. A. Perugini
Department of Biochemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia
R. C. J. Dobson, J. A. Gerrard
Biomolecular Interaction Centre, and School of Biological Sciences, University of Canterbury, Christchurch, New Zealand

Corresponding Author

Email: ashley.buckle@monash.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CFR AMB. Performed the experiments: CFR. Analyzed the data: CFR AMB. Contributed reagents/materials/analysis tools: CFR BTP. Wrote the paper: CFR MDWG RCJD MAP JAG AMB.